Szczuko Małgorzata, Golańska Justyna, Palma Joanna, Ziętek Maciej
Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, W. Broniewskiego 24, 71-460 Szczecin, Poland.
Department of Biochemical Sciences, Pomeranian Medical University, 70-204 Szczecin, Poland.
J Clin Med. 2023 Sep 15;12(18):5995. doi: 10.3390/jcm12185995.
Pregnancy is a physiological state in which the female body undergoes a series of changes and adaptations to provide the best possible conditions for the growth and development of the forming baby. The internal adaptations that take place lead to the production of inflammation, which is necessary for the initial and final stages of pregnancy (embryo implantation and induction of labor). Gestational diabetes mellitus is considered to be the most common pathology during this period. However, many more serious health complications can arise, which include pre-eclampsia, fetal stunting, and preterm labor. The purpose of this study was to analyze the impact of the levels of individual eicosanoids on the course of normal pregnancy and the possibility of pathologies including gestational diabetes and pre-eclampsia.
Sixty-nine pregnant women who were overweight or obese before and during pregnancy were studied. Eicosanoids were extracted as appropriate and then determined using liquid chromatography. The levels of eicosanoids studied in pregnant women differed not only according to the week of pregnancy but also in relation to individual anthropometric and biochemical parameters.
There was a significant correlation between being overweight and having a high BMI before pregnancy-as well as biochemical parameters of lipid and carbohydrate profiles-and the occurrence of pathological conditions in pregnancy.
Eicosanoids are involved in the pathology of pregnancy associated with the occurrence of gestational diabetes and pre-eclampsia. Salicylic acid may find use in the treatment of pregnant women exposed to both phenomena, as well as in overweight and obese women found before pregnancy. Diets rich in natural salicylates, methods of administration, and pharmacotherapy and dosage need further study. Some of the mediators (lipoxin, prostaglandin and leucotrien) may be new diagnostic markers in pregnancy pathology and intervention pathways in the future.
怀孕是一种生理状态，在此期间女性身体会经历一系列变化和适应过程，以为发育中的胎儿的生长和发育提供最佳条件。发生的内部适应会导致炎症产生，这在怀孕的初始和末期阶段（胚胎着床和引产）是必要的。妊娠期糖尿病被认为是这一时期最常见的病理状况。然而，还可能出现更多严重的健康并发症，包括先兆子痫、胎儿发育迟缓以及早产。本研究的目的是分析个体类二十烷酸水平对正常妊娠过程的影响以及包括妊娠期糖尿病和先兆子痫在内的病理状况发生的可能性。
对69名在孕前及孕期超重或肥胖的孕妇进行了研究。适当提取类二十烷酸，然后使用液相色谱法进行测定。孕妇体内所研究的类二十烷酸水平不仅因孕周不同而有所差异，还与个体人体测量学和生化参数有关。
孕前超重及高体重指数以及脂质和碳水化合物谱的生化参数与妊娠病理状况的发生之间存在显著相关性。
类二十烷酸参与了与妊娠期糖尿病和先兆子痫发生相关的妊娠病理过程。水杨酸可能可用于治疗同时出现这两种现象的孕妇，以及孕前超重和肥胖的女性。富含天然水杨酸盐的饮食、给药方法、药物治疗及剂量还需要进一步研究。一些介质（脂氧素、前列腺素和白三烯）可能在未来成为妊娠病理中的新诊断标志物和干预途径。
