阿昔洛韦治疗口腔面部单纯疱疹感染的综述

Treatment of oro-facial herpes simplex infections with acyclovir: a review.

作者信息

Perna J J, Eskinazi D P

机构信息

Division of Research Grants, National Institutes of Health, Bethesda, Md.

出版信息

Oral Surg Oral Med Oral Pathol. 1988 Jun;65(6):689-92. doi: 10.1016/0030-4220(88)90011-4.

DOI:10.1016/0030-4220(88)90011-4

PMID:3041335

Abstract

The treatment of herpes simplex virus (HSV) infections in the past has been largely unsuccessful. Introduction of the drug acyclovir has been a positive development. Acyclovir has been extensively studied in the treatment of a a variety of HSV infections in immunocompromised patients and in otherwise healthy patients. The results have shown it to effectively inhibit HSV replication but to have no effect in preventing or eliminating the latent state of the virus. It has been shown to be very effective in certain instances and not so effective in others.

摘要

过去，单纯疱疹病毒（HSV）感染的治疗大多未获成功。阿昔洛韦药物的引入是一项积极进展。阿昔洛韦已在免疫功能低下患者和其他健康患者中针对多种HSV感染的治疗进行了广泛研究。结果表明，它能有效抑制HSV复制，但对预防或消除病毒的潜伏状态没有作用。在某些情况下它已被证明非常有效，而在其他情况下则效果不佳。