复发性慢性绒毛间炎：诊断挑战——一例病例报告及文献综述
Recurrent Chronic Intervillositis: The Diagnostic Challenge - A Case Report and Review of the Literature.
作者信息
Hannaford Patricia, Mittal Namita, Sethna Farah, Dahlstrom Jane E
机构信息
ACT Pathology, The Canberra Hospital, Woden, Australia.
ACT Pathology, The Canberra Hospital, Woden, Australia.
出版信息
J Obstet Gynaecol Can. 2019 Mar;41(3):344-347. doi: 10.1016/j.jogc.2018.05.007. Epub 2018 Nov 7.
BACKGROUND
Chronic intervillositis (CI) is a rare placental condition involving diffuse infiltration of intervillous spaces by CD68- or CD45-positive maternal mononuclear inflammatory cells. Because no validated clinical or biochemical markers are specific to CI, the diagnosis is purely histopathological and is made postpartum.
CASE
This report describes a case of recurrent CI associated with adverse complications in two successive pregnancies. Both pregnancies were complicated by intrauterine growth restriction. Coexistent massive perivillous fibrin deposition was present in the first placenta. This case highlights the importance of CI in explaining and predicting adverse perinatal outcomes.
CONCLUSION
CI is associated with adverse pregnancy outcomes and a high risk of recurrence, and it can coexist with massive perivillous fibrin deposition. Pathologists must ensure that the significance of these diagnoses is adequately conveyed to clinicians, to optimize management of subsequent pregnancies.
背景
慢性绒毛间炎（CI）是一种罕见的胎盘疾病，其特征是绒毛间隙被CD68或CD45阳性的母体单核炎性细胞弥漫浸润。由于没有针对CI的经过验证的临床或生化标志物，诊断完全基于组织病理学，且在产后进行。
病例
本报告描述了一例在连续两次妊娠中与不良并发症相关的复发性CI病例。两次妊娠均合并宫内生长受限。第一个胎盘存在大量绒毛周围纤维蛋白沉积。该病例突出了CI在解释和预测围产期不良结局中的重要性。
结论
CI与不良妊娠结局及高复发风险相关，且可与大量绒毛周围纤维蛋白沉积共存。病理学家必须确保将这些诊断的意义充分传达给临床医生，以优化后续妊娠的管理。
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