Weber Martin A, Nikkels Peter G J, Hamoen Karen, Duvekot Johannes J, de Krijger Ronald R
Department of Pathology, Josephine Nefkens Institute, Erasmus MC-University Medical Center, Rotterdam, The Netherlands, and Department of Histopathology, Guy's and St Thomas' Hospital NHS Trust, London, UK.
Pediatr Dev Pathol. 2006 May-Jun;9(3):234-8. doi: 10.2350/06-01-0019.1.
Chronic intervillositis (CI) and massive perivillous fibrin deposition (MFD), together with its related entity, maternal floor infarction (MFI), are rare and poorly understood placental lesions. Both MFD/MFI and CI are associated with poor fetal outcome and high risk of recurrence. We report a patient who was found to have both MFD and CI in the same placenta, resulting in severe intrauterine fetal growth restriction and intrauterine fetal death at 37 weeks of gestation. Characteristic histological findings included both very extensive perivillous deposition of fibrinoid material and a heavy infiltrate of CD68-positive macrophages/monocytes in the maternal intervillous space. To our knowledge, this is the first time the co-occurrence of MFD and CI is reported in the literature.
慢性绒毛间炎（CI）和大量绒毛周围纤维蛋白沉积（MFD）及其相关病变——胎盘床梗死（MFI），是罕见且了解甚少的胎盘病变。MFD/MFI和CI均与不良胎儿结局及高复发风险相关。我们报告1例患者，其同一胎盘同时存在MFD和CI，导致妊娠37周时出现严重的胎儿宫内生长受限及胎儿宫内死亡。特征性组织学表现包括绒毛周围大量类纤维蛋白物质沉积以及母儿绒毛间隙内CD68阳性巨噬细胞/单核细胞大量浸润。据我们所知，这是文献中首次报道MFD和CI同时出现。
