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生长受限、骨质减少、胎盘大量绒毛周围纤维蛋白沉积伴(或不伴)绒毛间组织细胞及肾小管发育不全——一种新出现的复杂情况。

Growth Restriction, Osteopenia, Placental Massive Perivillous Fibrin Deposition With (or Without) Intervillous Histiocytes and Renal Tubular Dysgenesis-An Emerging Complex.

作者信息

Abdulghani Sahar, Moretti Felipe, Nikkels Peter Gj, Khung-Savatovsky Suonavy, Hurteau-Miller Julie, Grynspan David

机构信息

1 King Saud University hospital, Riyadh, Kingdom of Saudi Arabia.

2 Department of Obstetrics and Gynecology, The Ottawa Hospital and University of Ottawa, Ottawa, Canada.

出版信息

Pediatr Dev Pathol. 2018 Jan-Feb;21(1):91-94. doi: 10.1177/1093526617697061. Epub 2017 Mar 15.

Abstract

We describe a case of a pregnancy complicated by early onset asymmetric growth restriction with anhydramnios with termination occurring at 21 weeks. Fetal autopsy showed demineralization of bones and renal tubular dysgenesis. Placental pathology showed features of massive perivillous fibrin deposition and chronic histiocytic intervillositis. We review prior documentation of this association and briefly discuss potential pathogenesis.

摘要

我们描述了一例妊娠合并早发性不对称性生长受限及羊水过少的病例,于孕21周终止妊娠。胎儿尸检显示骨骼脱矿质及肾小管发育不全。胎盘病理显示大量绒毛周围纤维蛋白沉积及慢性组织细胞绒毛间炎的特征。我们回顾了此前关于这种关联的文献记录并简要讨论了潜在的发病机制。

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