Zhang Rui, Zhang Jianwu, Luo Wei, Luo Zhuang, Shi Shaoqing
Department of Thoracic Surgery, The Seventh People's Hospital of Chengdu, Chengdu, Sichuan, 640021, People's Republic of China.
School of Pharmacy, North Sichuan Medical College, Nanchong, Sichuan, 637100, People's Republic of China.
Pathol Oncol Res. 2019 Apr;25(2):443-446. doi: 10.1007/s12253-018-0506-5. Epub 2018 Nov 10.
WWP2 is an E3 ubiquitin ligase and plays an important role in regulation of many cellular biological activities through ubiquitination and degradation of its substrates. Recently accumulating evidences indicate that WWP2 plays a crucial part in the pathogenesis in different types of tumors. In this report, the role of this gene especially in tumorigenesis was reviewed. WWP2 is dysregulated in various of tumors, and it promotes carcinogenesis mainly through PTEN/Akt signaling pathway. WWP2 also participates in anti-cancer agents' sensitivity, indicating WWP2 may be a novel target for cancer treatment. WWP2 is one promising novel oncogene.
WWP2是一种E3泛素连接酶，通过对其底物进行泛素化和降解，在调控多种细胞生物学活性中发挥重要作用。最近越来越多的证据表明，WWP2在不同类型肿瘤的发病机制中起关键作用。在本报告中，对该基因尤其是在肿瘤发生中的作用进行了综述。WWP2在多种肿瘤中表达失调，主要通过PTEN/Akt信号通路促进肿瘤发生。WWP2还参与抗癌药物的敏感性，表明WWP2可能是癌症治疗的一个新靶点。WWP2是一个有前景的新型癌基因。
