Nasim Faria, Iyer Vivek N
Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
Ann Thorac Med. 2018 Oct-Dec;13(4):205-211. doi: 10.4103/atm.ATM_365_17.
Bronchial Thermoplasty is a procedure that involves the delivery of radiofrequency energy during bronchoscopy to airways in order to selectively ablate airway smooth muscles. Bronchial Thermoplasty was approved by the FDA in 2010 and remains the only device based non-pharmacological treatment approach for severe asthma. We appraise the trials leading to the approval of Bronchial Thermoplasty in light of the FDA approval process. Current international guidelines regarding use of Bronchial Thermoplasty and emering pharmacological options for severe asthma are reviewed.
支气管热成形术是一种在支气管镜检查期间向气道输送射频能量以选择性消融气道平滑肌的手术。支气管热成形术于2010年获得美国食品药品监督管理局(FDA)批准,仍然是重度哮喘唯一基于设备的非药物治疗方法。我们根据FDA的批准程序评估了导致支气管热成形术获批的试验。本文还综述了目前关于支气管热成形术使用的国际指南以及重度哮喘新出现的药物治疗选择。