Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, China University of Geosciences, Wuhan, 430074, China.
School of Chemical Engineering and Technology, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Xi'an Jiaotong University, Xi'an, 710049, China.
Macromol Rapid Commun. 2019 Feb;40(3):e1800541. doi: 10.1002/marc.201800541. Epub 2018 Nov 12.
Click-crosslinking has been widely used for the fabrication of nanocarriers in recent years. Crosslinking can enhance the stability of nanocarriers that have served as an emerging platform for drug delivery to achieve cancer diagnosis and therapy. In crosslinking methods, click reactions have attracted increasing attention owing to their high reaction specificity and physiologically stable products. These reports on click-crosslinked nanocarriers are divided into four sections (nanogels, nanoparticles, micelles, and capsules) according to the types of nanocarriers. Click-crosslinked nanocarriers enhance the solubility of hydrophobic drugs and improve the efficacy of drug delivery owing to their good stability. Stimuli-responsive and targeted strategies can be introduced into click-crosslinked nanocarriers to enhance drug accumulation in tumors.
点击交联近年来已被广泛用于纳米载体的制备。交联可以增强纳米载体的稳定性，纳米载体已成为药物递送的新兴平台，以实现癌症的诊断和治疗。在交联方法中，点击反应由于其高反应特异性和生理稳定的产物而受到越来越多的关注。这些关于点击交联纳米载体的报道根据纳米载体的类型分为四个部分（纳米凝胶、纳米粒子、胶束和胶囊）。点击交联纳米载体由于其良好的稳定性提高了疏水性药物的溶解度，并提高了药物递送的效果。刺激响应和靶向策略可以引入点击交联纳米载体中，以增强药物在肿瘤中的积累。
