Zhang Lumin, Si Xiaojia, Yang Yangyang, Zimmer Marc, Witzel Sina, Sekine Kohei, Rudolph Matthias, Hashmi A Stephen K
Organisch-Chemisches Institut, Heidelberg University, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Chemistry Department, Faculty of Science, King Abdulaziz University (KAU), Jeddah, 21589, Saudi Arabia.
Angew Chem Int Ed Engl. 2019 Feb 4;58(6):1823-1827. doi: 10.1002/anie.201810526. Epub 2019 Jan 9.
Herein we report a highly selective photoredox C(sp )-H alkylation/arylation of ethers through the combination of a photo-organocatalyst (benzaldehyde) and a transition-metal catalyst (nickel). This method provides a simple and general strategy for the C(sp )-H alkylation/arylation of ethers. A selective late-stage modification of (-)-ambroxide has also been conducted to demonstrate the applicability of the method.
在此，我们报道了通过光有机催化剂（苯甲醛）和过渡金属催化剂（镍）的组合，实现醚的高度选择性光氧化还原C(sp³)-H烷基化/芳基化反应。该方法为醚的C(sp³)-H烷基化/芳基化提供了一种简单通用的策略。我们还对（-）-龙涎醚进行了选择性后期修饰，以证明该方法的适用性。
