Rubba P, De Simone B, Postiglione A, Cortese C, Gnasso A, Mancini M
Institute of Internal Medicine and Metabolic Diseases, University of Naples, Italy.
Atherosclerosis. 1988 Jun;71(2-3):205-13. doi: 10.1016/0021-9150(88)90145-1.
Sixty-two patients (31 males, 31 females) with familial hypercholesterolemia (FH) underwent a vascular examination by Doppler ultrasound. The ankle/arm systolic pressure index was determined, and serum lipoproteins were analyzed. Eight of 124 legs examined (6.5%) showed an ankle/arm pressure index less than 0.95, suggesting flow reducing stenosis. Common carotid, internal carotid, and iliac arteries were evaluated by echo Doppler examination with spectral analysis. Forty-five of the 372 arteries examined (12.1%) had detectable abnormalities at echo Doppler examination. Iliac and internal carotid artery lesions were significantly (P less than 0.01) more frequent among FH patients than in a control group (30 men, 20 women) comparable for sex and age. The mean age of the patients with heterozygous FH and detectable arterial lesions was 45.3 years and that of those without lesions 30.7 years (P less than 0.05). When 14 patients with heterozygous FH and arterial lesions were compared to another 14 without lesions and matched for age and gender, it was found that patients with lesions had on average lower concentrations of HDL-cholesterol, and that 10 of 14 cases were actual smokers.
62例家族性高胆固醇血症（FH）患者（31例男性，31例女性）接受了多普勒超声血管检查。测定踝/臂收缩压指数，并分析血清脂蛋白。在检查的124条腿中，有8条（6.5%）显示踝/臂压力指数低于0.95，提示血流减少性狭窄。通过频谱分析的回声多普勒检查评估颈总动脉、颈内动脉和髂动脉。在检查的372条动脉中，有45条（12.1%）在回声多普勒检查中发现有异常。与年龄和性别匹配的对照组（30例男性，20例女性）相比，FH患者中髂动脉和颈内动脉病变明显更常见（P<0.01）。杂合子FH且有可检测到的动脉病变的患者平均年龄为45.3岁，无病变的患者平均年龄为30.7岁（P<0.05）。将14例有动脉病变的杂合子FH患者与另外14例年龄和性别匹配但无病变的患者进行比较时，发现有病变的患者平均HDL胆固醇浓度较低，且14例中有10例是实际吸烟者。
