Department of Internal Medicine, Salihli State Hospital, Manisa, Turkey.
Department of Internal Medicine, University of Health Sciences, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
Dis Markers. 2018 Oct 21;2018:2649392. doi: 10.1155/2018/2649392. eCollection 2018.
There is no specific marker that shows the disease activity in Behçet's disease.
In this study, we aimed to investigate VEGF-B and VEGF gene expressions and sTREM-1 levels in association with the activation of Behçet's disease.
Case-control study.
Clinical features of patients who applied in the rheumatology clinic and were diagnosed with BD according to the international working group's criteria were investigated. 30 healthy volunteers and 30 patients in the active period according to the EBDCAF scoring were studied. VEGF-B and VEGF gene expressions and sTREM-1 levels were studied in the serum samples of the patients and the control subjects.
The VEGF-B expressions and sTREM-1 levels were higher in the BD than those in the healthy group, but this difference did not reach statistical significance. VEGF gene expression was statistically significant ( = 0.008). Behçet's disease patients with oral aphthae, genital ulcer, eye, joint, vascular, skin, and neurological involvement were analyzed separately as subgroups. We find that VEGF gene expression level of Behçet's disease patients with joint involvement (arthritis/arthralgia) and also VEGF-B and VEGF gene expression of Behçet's disease with vascular involvement (DVT/thrombophlebitis) were significantly higher ( = 0.035, = 0.021). Each subgroup was analyzed with the control group. We determined that VEGF gene expression in all subgroups was significantly higher than that in the control group. At the same time, VEGF-B levels of patients with genital ulcer and vascular involvement (DVT/thrombophlebitis) were significantly higher than those in the control group.
VEGF-B and VEGF gene expressions can be activity indicators for BD. In addition, this study shows that new treatment options should be explored for Behçet's disease patients with joint and vascular involvement. In the following years, new treatment methods are needed to investigate for revealing the role of the etiopathogenesis of BD and the activation and prognosis of VEGF by examining this study and providing much more participation. In our study group, the sTREM-1 levels were high but the results did not reach statistical significance. More studies are needed with larger groups in order the highlight the exact role of STREM-1 in Behçet's disease.
目前尚无特定标志物可显示白塞病的疾病活动度。
本研究旨在探讨 VEGF-B 和 VEGF 基因表达及可溶性髓系细胞触发受体-1（sTREM-1）水平与白塞病活动的关系。
病例对照研究。
对因临床症状就诊于风湿科门诊，并根据国际工作组标准诊断为 BD 的患者进行临床特征调查。研究了 30 名健康志愿者和 30 名根据 EBDCAF 评分处于活动期的患者。检测了患者和对照组血清样本中的 VEGF-B 和 VEGF 基因表达及 sTREM-1 水平。
BD 患者的 VEGF-B 表达和 sTREM-1 水平高于健康对照组，但差异无统计学意义。VEGF 基因表达具有统计学意义（ = 0.008）。将有口腔阿弗他溃疡、生殖器溃疡、眼、关节、血管、皮肤和神经受累的白塞病患者分别作为亚组进行分析。我们发现，伴有关节（关节炎/关节痛）受累和血管（深静脉血栓形成/血栓性静脉炎）受累的白塞病患者的 VEGF 基因表达水平（ = 0.035， = 0.021）以及 VEGF-B 和 VEGF 基因表达均显著升高。我们对每个亚组与对照组进行了分析，结果显示所有亚组的 VEGF 基因表达均显著高于对照组。同时，伴有生殖器溃疡和血管（深静脉血栓形成/血栓性静脉炎）受累的患者的 VEGF-B 水平也显著高于对照组。
VEGF-B 和 VEGF 基因表达可作为 BD 的活动指标。此外，本研究表明，对于伴有关节和血管受累的白塞病患者，应探索新的治疗选择。在未来的几年里，需要通过这项研究和提供更多的参与，来研究新的治疗方法，以揭示白塞病的发病机制和 VEGF 的激活及预后的作用，并开展更多的研究。在我们的研究组中，sTREM-1 水平较高，但结果无统计学意义。需要更大的研究组来突出 sTREM-1 在白塞病中的确切作用。
