Hamzaoui Kamel, Ayed Khaled, Hamza M'Hamed, Hamzaoui Agnès
Medicine University Tunis, Department of Basic Sciences, 15 rue Djebel Lakdar, Unit research (99/08-40), Homeostasis and Cell Dysfunction, Tunis, Tunisia.
J Neuroimmunol. 2009 Aug 18;213(1-2):148-53. doi: 10.1016/j.jneuroim.2009.05.005. Epub 2009 Jun 2.
Vascular endothelial growth factor (VEGF) stimulates angiogenesis, but is also pro-inflammatory and plays an important role in the development of neurological disease, where it can have both attenuating and exacerbating effects. Several studies have indicated that VEGF-A (VEGF) may play a role in the pathogenesis of neurological inflammatory diseases. To assess the role of VEGF in patients with Behçet's disease with neurological involvement, VEGF was measured in the cerebrospinal fluid (CSF) of 32 patients compared to a group of 12 patients with noninflammatory neurological diseases (NIND) and 14 patients with multiple sclerosis (MS). We have also studied the expression of mRNA-VEGF (VEGF-A) in CSF and in peripheral blood mononuclear cells. The mean VEGF(CSF) was significantly increased in neuro-BD and MS patients compared to NIND patients. There was an association between neuro-BD-VEGF(CSF), and leukocyte count. A significant correlation was also observed between neuro-BD-VEGF(CSF) and CSF(%CD4) cells. As a measure of the integrity of the blood-brain barrier Q(albumin) was found correlated to VEGF(CSF). VEGF mRNA was significantly increased in neuro-BD patients compared to NIND patients. These results indicate that, VEGF may be associated with the increased percentages of CD4 cell subpopulation. The role of VEGF is within the inflammatory cascade in the mediation of blood-brain barrier disruption and not specific to Behçet's.
血管内皮生长因子（VEGF）可刺激血管生成，但也具有促炎作用，在神经疾病的发展中起重要作用，它可能产生减轻和加重两种效应。多项研究表明，VEGF-A（VEGF）可能在神经炎性疾病的发病机制中起作用。为评估VEGF在伴有神经受累的白塞病患者中的作用，我们检测了32例患者脑脊液（CSF）中的VEGF，并与12例非炎性神经疾病（NIND）患者及14例多发性硬化症（MS）患者组成的对照组进行比较。我们还研究了CSF和外周血单个核细胞中mRNA-VEGF（VEGF-A）的表达。与NIND患者相比，神经白塞病和MS患者的平均VEGF（CSF）显著升高。神经白塞病患者的CSF-VEGF与白细胞计数之间存在关联。神经白塞病患者的CSF-VEGF与CSF（%CD4）细胞之间也观察到显著相关性。作为血脑屏障完整性指标的Q（白蛋白）与VEGF（CSF）相关。与NIND患者相比，神经白塞病患者的VEGF mRNA显著升高。这些结果表明，VEGF可能与CD4细胞亚群百分比增加有关。VEGF的作用在于炎症级联反应中介导血脑屏障破坏，并非白塞病所特有。
