Gankyrin 通过激活 mTORC1 驱动胃癌的恶性转化并减轻氧化应激。

Department of Oncology, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, 280 Mohe Road, Shanghai 201999, China.

Oxid Med Cell Longev. 2018 Oct 21;2018:9480316. doi: 10.1155/2018/9480316. eCollection 2018.

Gastric cancer, as a malignant epithelial tumor, is a major health threat leading to poor overall survival and death. It is usually diagnosed at an advanced stage due to asymptomatic or only nonspecific early symptoms. The present study demonstrated that gankyrin contributes to the early malignant transformation of gastric cancer and can be selected to predict the risk of gastric cancer in those patients harboring the precancerous lesions (dysplasia and intestinal metaplasia). In addition, a new insight into gastric cancer was provided, which stated that gankyrin alleviates oxidative stress via mTORC1 pathway activation. It can potentiate the mTORC1 by PGK1-AKT signaling that promotes the tumor process, and this phenomenon is not completely consistent with the previous report describing colorectal cancer.

胃癌是一种恶性上皮肿瘤，是导致整体生存率和死亡率较差的主要健康威胁。由于无症状或仅有非特异性早期症状，通常在晚期才被诊断出来。本研究表明，gankyrin 有助于胃癌的早期恶性转化，并可用于预测那些患有癌前病变（发育不良和肠化生）的患者患胃癌的风险。此外，本研究还提供了一个关于胃癌的新见解，即 gankyrin 通过激活 mTORC1 通路来减轻氧化应激。它可以通过 PGK1-AKT 信号增强 mTORC1，促进肿瘤的发生，这种现象与以前描述结直肠癌的报告不完全一致。