胞吐作用的分子机制：以肾上腺嗜铬细胞作为模型系统
Molecular mechanisms of exocytosis: the adrenal chromaffin cell as a model system.
作者信息
Strittmatter W J
机构信息
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
出版信息
Cell Mol Neurobiol. 1988 Mar;8(1):19-25. doi: 10.1007/BF00712907.
Abstract
- The release of neurotransmitters, hormones, and enzymes involves exquisitely regulated events which ultimately result in the fusion of the secretory vesicle with the cell's plasma membrane, releasing the vesicle contents into the extracellular space. 2. The biochemical and cellular mechanisms mediating exocytosis have been extensively studied in a model system of primary cultured adrenal chromaffin cells. 3. This paper briefly reviews current understanding, and directions of future studies in exocytosis using this model system.
摘要
- 神经递质、激素和酶的释放涉及一系列精确调控的事件，这些事件最终导致分泌囊泡与细胞质膜融合，将囊泡内容物释放到细胞外空间。2. 在原代培养的肾上腺嗜铬细胞模型系统中，对介导胞吐作用的生化和细胞机制进行了广泛研究。3. 本文简要回顾了利用该模型系统对胞吐作用的当前认识以及未来研究方向。
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本文引用的文献
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J Neurochem. 1981 Mar;36(3):847-54. doi: 10.1111/j.1471-4159.1981.tb01671.x.
2
Interaction of calmodulin with adrenal chromaffin granule membranes.钙调蛋白与肾上腺嗜铬粒膜的相互作用。
FEBS Lett. 1982 Jun 21;143(1):69-72. doi: 10.1016/0014-5793(82)80275-5.
3
Relationship between Ca2+ uptake and catecholamine secretion in primary dissociated cultures of adrenal medulla.肾上腺髓质原代解离培养物中钙离子摄取与儿茶酚胺分泌之间的关系。
J Neurochem. 1982 Sep;39(3):635-46. doi: 10.1111/j.1471-4159.1982.tb07940.x.
4
Chromaffin granule membrane-F-actin interactions are calcium sensitive.嗜铬粒细胞膜与丝状肌动蛋白的相互作用对钙敏感。
Nature. 1982 Jan 28;295(5847):336-9. doi: 10.1038/295336a0.
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The microtrabecular lattice of the adrenal medulla revealed by polyethylene glycol embedding and stereo electron microscopy.通过聚乙二醇包埋和立体电子显微镜揭示的肾上腺髓质微小梁晶格。
J Neurosci. 1982 Jan;2(1):57-65. doi: 10.1523/JNEUROSCI.02-01-00057.1982.
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