Foss Michael G., Hashmi Muhammad F., Ferrer-Bruker Sarah J.
National Health Service
VCOM/Orange Park Medical Center
Necrolytic migratory erythema (NME) is a characteristic skin rash most often associated with glucagonoma, an alpha-cell tumor of the pancreatic islets. It is usually seen as a part of the glucagonoma syndrome, a paraneoplastic syndrome that includes the triad of diabetes mellitus, NME, and weight loss. However, more rarely, NME can also be seen as a part of other clinical entities such as liver disease and intestinal malabsorption; here, it is termed the pseudoglucagonoma syndrome. The skin rash is characteristically extremely erythematous, shows superficial epidermal necrosis, and often spreads in a centrifugal pattern. The condition is frequently misdiagnosed due in part to its rarity. It is the presenting symptom of the pancreatic islet neoplasm. Thus, timely recognition and treatment can help prevent morbidity from the epidermal dysfunction and mortality from the tumor burden itself if the neoplasm is identified before metastasis.
坏死性游走性红斑（NME）是一种特征性皮疹，最常与胰岛α细胞瘤——胰高血糖素瘤相关。它通常被视为胰高血糖素瘤综合征的一部分，这是一种副肿瘤综合征，包括糖尿病、NME和体重减轻三联征。然而，更罕见的是，NME也可作为其他临床疾病的一部分出现，如肝病和肠道吸收不良；在此情况下，它被称为假性胰高血糖素瘤综合征。这种皮疹的特征是极度红斑，表现为表皮浅层坏死，且常呈离心性扩散。由于其罕见性，该病常被误诊。它是胰岛肿瘤的首发症状。因此，如果在肿瘤转移前确诊，及时识别和治疗有助于预防表皮功能障碍导致的发病以及肿瘤负荷本身导致的死亡。
