Dargent F J, Fox L E, Anderson W I
Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Cornell Vet. 1988 Jul;78(3):253-62.
Neoplastic angioendotheliomatosis was diagnosed in a nine-year-old, intact male German Shorthaired Pointer exhibiting progressive neurological signs over a six-month period. At necropsy, there was multifocal asymmetric, hemorrhagic necrosis within the cerebral hemispheres, centrum semiovale, caudate nucleus, and internal capsule. Histologically, there was extensive intravascular proliferation of pleomorphic mononuclear cells within the brain and multiple parenchymatous organs. Transmission electron microscopy demonstrated the absence of intercellular junctions between neoplastic cells. These cells were not attached to the vascular lining endothelium; Weibel-Palade bodies and a basement membrane were lacking. By indirect immunofluorescence, positive cytoplasmic staining of intravascular neoplastic cells for IgG was demonstrated. Peroxidase-antiperoxidase technique for Factor VIII related antigen was negative. As in man, this rare neoplastic disorder appears to be a lymphoma, apparently of the B cell line.
在一只9岁、未绝育的雄性德国短毛指示犬中诊断出肿瘤性血管内皮瘤病，该犬在6个月内出现进行性神经症状。尸检时，在大脑半球、半卵圆中心、尾状核和内囊内有多处不对称的出血性坏死。组织学上，在脑和多个实质器官内有大量多形性单核细胞的血管内增生。透射电子显微镜显示肿瘤细胞之间不存在细胞间连接。这些细胞未附着于血管内衬内皮；缺乏魏尔-帕拉德小体和基底膜。通过间接免疫荧光法，显示血管内肿瘤细胞的细胞质对IgG呈阳性染色。因子VIII相关抗原的过氧化物酶-抗过氧化物酶技术为阴性。与人类一样，这种罕见的肿瘤性疾病似乎是一种淋巴瘤，显然是B细胞系的。
