Molecular Biology Center, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China; State Key Laboratory of Trauma, Burn and Combined Injury, Army Medical University, Chongqing, 400038, China; Collaborative Innovation Center for Brain Science, Army Medical University, Chongqing, 400038, China.
Molecular Biology Center, Research Institute of Surgery and Daping Hospital, Army Medical University, Chongqing, 400042, China.
Toxicol Lett. 2019 Feb;301:90-97. doi: 10.1016/j.toxlet.2018.11.004. Epub 2018 Nov 10.
Caffeine is a substance that is consumed worldwide, and it may exert neuroprotective effects against various cerebral insults, including neurotrauma, which is the most prevalent injury among military personnel. To investigate the effects of caffeine on high-intensity blast wave-induced severe blast injury in mice, three different paradigms of caffeine were applied to male C57BL/6 mice with severe whole body blast injury (WBBI). The results demonstrated that chronic caffeine treatment alleviated blast-induced traumatic brain injury (bTBI); however, both chronic and acute caffeine treatments exacerbated blast-induced lung injuries and, more importantly, increased both the cumulative and time-segmented mortalities postinjury. Interestingly, withdrawing caffeine intake preinjury resulted in favorable outcomes in mortality and lung injury, similar to the findings in water-treated mice, and had the trend to attenuate brain injury. These findings demonstrated that although drinking coffee or caffeine preparations attenuated blast-induced brain trauma, these beverages may place personnel in the battlefield at high risk of casualties, which will help us re-evaluate the therapeutic strategy of caffeine application, particularly in multiple-organ-trauma settings. Furthermore, these findings provided possible strategies for reducing the risk of casualties with caffeine consumption, which may help to change the coffee-drinking habits of military personnel.
咖啡因是一种在全球范围内被消耗的物质，它可能对各种脑损伤产生神经保护作用，包括神经创伤，这是军事人员中最常见的损伤。为了研究咖啡因对高强度冲击波引起的严重爆炸伤的影响，将三种不同的咖啡因方案应用于雄性 C57BL/6 小鼠的全身严重爆炸伤（WBBI）。结果表明，慢性咖啡因治疗减轻了爆炸引起的创伤性脑损伤（bTBI）；然而，慢性和急性咖啡因治疗均加重了爆炸引起的肺损伤，更重要的是，增加了损伤后的累积和时间分段死亡率。有趣的是，损伤前停止摄入咖啡因可提高死亡率和肺损伤的预后，类似于水治疗组的发现，并具有减轻脑损伤的趋势。这些发现表明，尽管喝咖啡或咖啡因制剂可减轻爆炸引起的脑外伤，但这些饮料可能会使战场上的人员伤亡风险增加，这将有助于我们重新评估咖啡因应用的治疗策略，特别是在多器官创伤的情况下。此外，这些发现为减少咖啡因摄入导致的伤亡风险提供了可能的策略，这可能有助于改变军事人员的喝咖啡习惯。
