Cai Jia, Hu Xiao, Guo Kuifang, Yang Pingyuan, Situ Mingjing, Huang Yi
Mental Health Center, West China Hospital of Sichuan University, Chengdu, China.
Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Front Psychiatry. 2018 Oct 30;9:542. doi: 10.3389/fpsyt.2018.00542. eCollection 2018.
Previous neuroimaging studies of autism spectrum disorder (ASD) have focused on subjects with IQ > 70 or ASD without considering IQ levels. It remains unclear whether differences in brain anatomy in this population are associated with variations in clinical phenotype. In this study, 19 children with low functioning autism (LFA) and 19 children with high functioning autism (HFA) were compared with 27 healthy controls (HC). We found increased gray matter volume (GMV) in the left inferior temporal gyrus in subjects with both HFA and LFA and increased GMV of left middle temporal gyrus BA21 was found only in the LFA group. A significant negative correlation was found between the left inferior temporal gyrus (LITG) and the score of repetitive behavior in the HFA group.
先前关于自闭症谱系障碍（ASD）的神经影像学研究主要集中在智商高于70的受试者或未考虑智商水平的自闭症患者身上。目前尚不清楚该人群的脑解剖结构差异是否与临床表型的变化有关。在本研究中，将19名低功能自闭症（LFA）儿童和19名高功能自闭症（HFA）儿童与27名健康对照（HC）进行了比较。我们发现，HFA和LFA受试者的左侧颞下回灰质体积（GMV）均增加，而仅在LFA组中发现左侧颞中回BA21的GMV增加。在HFA组中，左侧颞下回（LITG）与重复行为得分之间存在显著负相关。
