两例与放射相关的乳腺血管肉瘤
Two cases of radiation-associated angiosarcoma of the breast.
作者信息
Nomoto Yuki, Kijima Yuko, Shinden Yoshiaki, Hirata Munetugu, Eguchi Yuka, Yoshinaka Heiji, Kitazono Ikumi, Hiraki Tsubasa, Tanimoto Akihide, Natsugoe Shoji
机构信息
Department of Digestive Surgery, Breast and Thyroid Surgery, Kagoshima University Hospital, 37-1 Uearata, Kagoshima, 890-0055, Japan.
Department of Breast Surgery, Kagoshima City Hospital, Kagoshima, Japan.
出版信息
Surg Case Rep. 2018 Nov 13;4(1):132. doi: 10.1186/s40792-018-0539-8.
BACKGROUND
The incidence of radiation-associated angiosarcoma (RAA) of the breast has been increasing, and its prognosis is reportedly poor. It is important to remove tumor tissues completely to prevent recurrence.
CASE PRESENTATION
We report two cases of patients with RAA of the breast. Both patients had a nodule in their remaining breast a few years after undergoing breast-conserving surgery and radiation therapy for breast cancer. The nodules were diagnosed as angiosarcoma by skin biopsy and open biopsy, respectively. To determine the extent of lesion spread, mapping biopsy was performed before surgery. Both patients underwent mastectomy, extensive skin resection, and split skin grafting. Pathological findings showed that their tumors could be completely resected. After surgery, chemotherapy was performed.
CONCLUSION
In our cases, no local or distant recurrence has been detected in either patient for over 4 years. We identified the range of tumor invasion by preoperative mapping biopsy and completely resected all tumor tissue.
背景
乳腺放射性相关血管肉瘤（RAA）的发病率一直在上升，据报道其预后较差。彻底切除肿瘤组织对于预防复发很重要。
病例报告
我们报告两例乳腺RAA患者。两名患者在因乳腺癌接受保乳手术和放射治疗几年后，其留存乳房中均出现一个结节。这些结节分别通过皮肤活检和切开活检被诊断为血管肉瘤。为确定病变扩散范围，术前进行了定位活检。两名患者均接受了乳房切除术、广泛的皮肤切除和中厚皮片移植术。病理结果显示其肿瘤可被完全切除。术后进行了化疗。
结论
在我们的病例中，两名患者均在超过4年的时间里未检测到局部或远处复发。我们通过术前定位活检确定了肿瘤侵犯范围，并完全切除了所有肿瘤组织。
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