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双侧乳腺发生的放射性血管肉瘤：一例报告

Radiation-Induced Angiosarcoma Arising in Bilateral Breast: A Case Report.

作者信息

Tsuji Wakako, Yoshikawa Katsuhiro, Fujisawa Fumie, Yamauchi Chikako, Sugimoto Akihiko

机构信息

Department of Breast Surgery, Shiga General Hospital, Moriyama, JPN.

Department of Plastic Surgery, Shiga General Hospital, Moriyama, JPN.

出版信息

Cureus. 2024 Sep 6;16(9):e68782. doi: 10.7759/cureus.68782. eCollection 2024 Sep.

DOI:10.7759/cureus.68782
PMID:39371746
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11456261/
Abstract

Radiation-induced angiosarcoma is a highly aggressive malignancy. We encountered a case of angiosarcoma arising in the bilateral breast seven years after partial mastectomy and the last radiation therapy. As recommended, wide resection with skin grafting was performed to ensure negative surgical margins. After surgery, taxane-based chemotherapy was administered. However, adjuvant chemotherapy was discontinued because of drug-induced institutional pneumonia. Eighteen months postoperatively, angiosarcoma recurred in subcutaneous, lymph nodes, lungs, and bones. The disease progressed too rapidly, and the patient died two months after recurrence.

摘要

放射性血管肉瘤是一种高度侵袭性的恶性肿瘤。我们遇到一例在部分乳房切除术后七年和最后一次放疗后双侧乳房发生血管肉瘤的病例。按照建议，进行了带皮肤移植的广泛切除以确保手术切缘阴性。手术后，给予了紫杉烷类化疗。然而，由于药物引起的院内肺炎，辅助化疗中断。术后18个月，血管肉瘤在皮下、淋巴结、肺和骨复发。疾病进展太快，患者在复发后两个月死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/adae0e0e3e56/cureus-0016-00000068782-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/55bb0c3a659c/cureus-0016-00000068782-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/aa96661955df/cureus-0016-00000068782-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/b02a0d8a4309/cureus-0016-00000068782-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/14dbaa9e2944/cureus-0016-00000068782-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/083a2a6d10a2/cureus-0016-00000068782-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/adae0e0e3e56/cureus-0016-00000068782-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/55bb0c3a659c/cureus-0016-00000068782-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/aa96661955df/cureus-0016-00000068782-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/b02a0d8a4309/cureus-0016-00000068782-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/14dbaa9e2944/cureus-0016-00000068782-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/083a2a6d10a2/cureus-0016-00000068782-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6216/11456261/adae0e0e3e56/cureus-0016-00000068782-i06.jpg

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本文引用的文献

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Educational Case: Radiation-Induced Angiosarcoma of the Breast.教育案例：乳腺放射性血管肉瘤
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Assessment of Radiotherapy-Associated Angiosarcoma After Breast Cancer Treatment in a Dutch Population-Based Study.荷兰基于人群的研究评估乳腺癌治疗后放疗相关的血管肉瘤。
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Two cases of radiation-associated angiosarcoma of the breast.两例与放射相关的乳腺血管肉瘤
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Radiation-Induced Angiosarcoma after Breast-Cancer Treatment.乳腺癌治疗后放射性血管肉瘤
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Pazopanib in advanced vascular sarcomas: an EORTC Soft Tissue and Bone Sarcoma Group (STBSG) retrospective analysis.帕唑帕尼治疗晚期血管肉瘤：一项欧洲癌症研究与治疗组织软组织和骨肉瘤组（STBSG）的回顾性分析。
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