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使未愈合者愈合:对于最初采用髓内钉治疗的股骨干骨折不愈合,是否应采用钢板加强而非更换髓内钉进行治疗?一项系统评价

Uniting the un-united: should established non-unions of femoral shaft fractures initially treated with IM nails be treated by plate augmentation instead of exchange IM nailing? A systematic review.

作者信息

Medlock Gareth, Stevenson Iain M, Johnstone Alan J

机构信息

Trauma and Orthopaedic Unit, Aberdeen Royal Infirmary, Wards 212/213, Foresterhill, Aberdeen, AB25 2ZN, UK.

出版信息

Strategies Trauma Limb Reconstr. 2018 Nov;13(3):119-128. doi: 10.1007/s11751-018-0323-0. Epub 2018 Nov 13.

DOI:10.1007/s11751-018-0323-0
PMID:30426320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6249146/
Abstract

The majority of femoral fractures are surgically treated with intramedullary nails. Non-union rate is low but challenging and costly if it occurs. There have been encouraging results from the use of augmentative plating as a treatment for non-union of femoral fractures. We performed a systematic review of the literature to compare union rates, time to union and complications between exchange nailing and augmentative plating as a primary procedure following a diagnosis of femoral non-union following initial nailing. We found a total of 21 papers, which found the mean union rate of augmentative plating to be 99.8% compared to 74% (P = 2.05) found for exchange nailing. Times to union were comparable at 5.9 months for augmentative plating and 6.3 months for exchange nailing (P = 0.68916), and complication rate was 4% for augmentative plating compared to 20% for exchange nailing. From the evidence available, plate augmentation provides a more reliable union rate if used as the first operative intervention on a non-union of a femoral fracture compared to exchange nailing.Level of Evidence IV Systematic review of therapeutic studies.

摘要

大多数股骨骨折采用髓内钉进行手术治疗。骨不连发生率较低,但一旦发生则具有挑战性且成本高昂。使用增强钢板治疗股骨骨折骨不连已取得令人鼓舞的成果。我们对文献进行了系统综述,以比较在初次髓内钉固定后诊断为股骨骨不连时,更换髓内钉和增强钢板作为主要治疗方法的骨愈合率、骨愈合时间及并发症情况。我们共找到21篇论文,其中增强钢板的平均骨愈合率为99.8%,而更换髓内钉的骨愈合率为74%(P = 2.05)。增强钢板的骨愈合时间为5.9个月,更换髓内钉为6.3个月,二者相当(P = 0.68916),增强钢板的并发症发生率为4%,更换髓内钉为20%。根据现有证据,与更换髓内钉相比,若将钢板增强作为股骨骨折骨不连的首次手术干预措施,其骨愈合率更可靠。证据级别IV 治疗性研究的系统综述

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34cb/6249146/fc6f1d650ca3/11751_2018_323_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34cb/6249146/fc6f1d650ca3/11751_2018_323_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/34cb/6249146/fc6f1d650ca3/11751_2018_323_Fig1_HTML.jpg

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J Clin Med. 2024 Feb 29;13(5):1414. doi: 10.3390/jcm13051414.
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Plate augmentation and hybrid bone grafting are effective treatments for atrophic nonunion of the femur with the original intramedullary nail retained in situ.

本文引用的文献

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Exchange nailing for femoral diaphyseal fracture non-unions: Risk factors for failure.股骨干骨折不愈合的交锁髓内钉固定:失败的危险因素
Injury. 2015 Dec;46(12):2404-9. doi: 10.1016/j.injury.2015.09.027. Epub 2015 Oct 8.
2
Is augmentation plating an effective treatment for non-union of femoral shaft fractures with nail in situ?带锁髓内钉固定后股骨干骨折不愈合采用接骨板补充固定治疗是否有效?
Eur J Trauma Emerg Surg. 2016 Jun;42(3):339-43. doi: 10.1007/s00068-015-0534-8. Epub 2015 Apr 29.
3
Augmentation plating in hypertrophic non-union after nail fixation of femoral shaft fracture compared with exchange plating.
钢板增强和混合植骨是治疗股骨萎缩性不愈合的有效方法,保留原位的原始髓内钉。
Sci Rep. 2024 Mar 26;14(1):7089. doi: 10.1038/s41598-024-57809-1.
4
What Is the Best Treatment of the Femoral Shaft Nonunion after Intramedullary Nailing? A Systematic Review.髓内钉固定术后股骨干骨不连的最佳治疗方法是什么?一项系统评价。
Life (Basel). 2023 Jul 4;13(7):1508. doi: 10.3390/life13071508.
5
Augmentative Plating versus Exchange Intramedullary Nailing for the Treatment of Aseptic Non-Unions of the Femoral Shaft-A Biomechanical Study in a Sawbone Model.增强钢板与交锁髓内钉治疗股骨干无菌性骨不连的对比研究——基于锯骨模型的生物力学研究
J Pers Med. 2023 Apr 10;13(4):650. doi: 10.3390/jpm13040650.
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A comparison of exchange nailing and plate augmentation over a retained intramedullary nail in aseptic oligotrophic and atrophic femoral shaft pseudoarthrosis.保留髓内钉的情况下,比较交锁钉和钢板增强治疗无菌性少血供和萎缩性股骨干假关节。
Jt Dis Relat Surg. 2023;34(1):121-129. doi: 10.52312/jdrs.2023.788. Epub 2023 Jan 14.
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World J Orthop. 2022 May 18;13(5):528-537. doi: 10.5312/wjo.v13.i5.528.
股骨干骨折髓内钉固定后肥大性骨不连的增强钢板固定与更换钢板固定的比较
Chin Med J (Engl). 2014;127(16):2900-5.
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Results of a systematic approach to exchange nailing for the treatment of aseptic femoral nonunions.采用交锁髓内钉治疗无菌性股骨骨不连的系统方法的结果。
J Orthop Trauma. 2015 Jan;29(1):21-7. doi: 10.1097/BOT.0000000000000166.
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Injury. 2013 Dec;44(12):1820-5. doi: 10.1016/j.injury.2013.02.021. Epub 2013 Mar 16.
6
Effectiveness of plate augmentation for femoral shaft nonunion after nailing.钢板增强治疗髓内钉固定后股骨干骨不连的疗效。
J Chin Med Assoc. 2012 Aug;75(8):396-401. doi: 10.1016/j.jcma.2012.06.008. Epub 2012 Jul 24.
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Augmentative locking compression plate fixation for the management of long bone nonunion after intramedullary nailing.带锁髓内钉固定后长骨骨不连的补充性锁定加压接骨板固定治疗。
Arch Orthop Trauma Surg. 2012 Jul;132(7):937-40. doi: 10.1007/s00402-012-1497-4. Epub 2012 Mar 7.
8
Plate fixation of femoral nonunions over an intramedullary nail with autogenous bone grafting.带髓内钉自体植骨治疗股骨干骨不连的钢板固定术。
J Orthop Trauma. 2011 Feb;25(2):84-9. doi: 10.1097/BOT.0b013e3181dfbb33.
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Failed intramedullary nailing of femur: open reduction and plate augmentation with the nail in situ.股骨干髓内钉固定失败:切开复位并在原位使用钢板加强髓内钉。
Int Orthop. 2011 Jul;35(7):1089-92. doi: 10.1007/s00264-010-1192-4. Epub 2011 Jan 11.
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Orthopedics. 2010 Jun 9;33(6):393. doi: 10.3928/01477447-20100429-18.