Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China.
Org Biomol Chem. 2019 Feb 13;17(7):1763-1766. doi: 10.1039/c8ob02575d.
Chiral selenide-catalyzed enantioselective trifluoromethylthiolation of 1,1-disubstituted alkenes is disclosed. By this method, a variety of chiral trifluoromethylthiolated 2,5-disubstituted oxazolines were obtained in good yields with high enantioselectivities. This work not only provides a new pathway for the synthesis of chiral oxazolines, but also expands the library of chiral trifluoromethylthiolated molecules.
手性硒化物催化的 1,1-二取代烯烃的对映选择性三氟甲硫基化反应被揭示。通过该方法，多种手性三氟甲硫基化 2,5-二取代恶唑啉以高产率和高对映选择性得到。这项工作不仅为手性恶唑啉的合成提供了新途径，而且扩展了手性三氟甲硫基化分子的库。
