手性硒化物催化的对映选择性饱和三氟甲基硫代氮杂环的构建。
Chiral Selenide-Catalyzed Enantioselective Construction of Saturated Trifluoromethylthiolated Azaheterocycles.
机构信息
Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University , Guangzhou 510275, P. R. China.
出版信息
Org Lett. 2017 Jul 7;19(13):3434-3437. doi: 10.1021/acs.orglett.7b01392. Epub 2017 Jun 20.
PMID:28632389
Abstract
An indane-based, bifunctional, chiral selenide catalyst has been developed. The new catalyst is efficient for the enantioselective synthesis of saturated azaheterocycles possessing a trifluoromethylthio group. The desired products were obtained in good yields with high diastereo- and enantioselectivities.
摘要
一种基于茚满的双功能手性硒化物催化剂已经被开发出来。该新型催化剂对于具有三氟甲硫基的饱和氮杂环化合物的对映选择性合成非常有效。所需产物以高非对映选择性和对映选择性获得，产率良好。
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