载灯盏花素介孔硅纳米粒的聚乳酸-羟基乙酸共聚物电纺膜用于长效抗菌创伤敷料。
Electrospun PLGA membrane incorporated with andrographolide-loaded mesoporous silica nanoparticles for sustained antibacterial wound dressing.
机构信息
School of Mechanical & Power Engineering, Complex and Intelligent Systems Research Centre, East China University of Science & Technology, Shanghai 200237, China.
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
出版信息
Nanomedicine (Lond). 2018 Nov;13(22):2881-2899. doi: 10.2217/nnm-2018-0099. Epub 2018 Nov 14.
AIM
To assess the wound-healing ability of poly(lactic-co-glycolic acid) (PLGA) nanofibrous wound dressing incorporated with andrographolide (Andro)-loaded mesoporous silica nanoparticles (MSNs).
MATERIALS & METHODS: PLGA/Andro-MSNs nanofibrous membrane wound dressings were produced by electrospinning. The effects of MSNs on the hydrophilicity, degradation and mechanical strength of membranes were evaluated. The cumulative release of Andro in vitro was obtained. Cell culture and in vivo tests on infectious models were carried out.
RESULTS
The PLGA/Andro-MSNs membrane showed a sustained release of Andro. The incorporation of MSNs into PLGA improved the hydrophilicity of the nanofibrous membranes. Cell culture and in vivo tests showed that PLGA/Andro-MSNs membrane can promote epidermal cell adhesion and reduce inflammation process.
CONCLUSION
PLGA/Andro-MSNs nanofibrous membrane exhibited an efficient wound-healing ability.
目的
评估载穿心莲内酯（Andro）介孔硅纳米粒子（MSNs）的聚乳酸-共-羟基乙酸（PLGA）纳米纤维敷料的伤口愈合能力。
材料与方法
通过静电纺丝制备 PLGA/Andro-MSNs 纳米纤维膜。评估 MSNs 对膜亲水性、降解和机械强度的影响。体外获得 Andro 的累积释放。进行细胞培养和感染模型的体内试验。
结果
PLGA/Andro-MSNs 膜表现出 Andro 的持续释放。MSNs 的掺入提高了纳米纤维膜的亲水性。细胞培养和体内试验表明，PLGA/Andro-MSNs 膜可促进表皮细胞黏附并减少炎症过程。
结论
PLGA/Andro-MSNs 纳米纤维膜具有高效的伤口愈合能力。
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