University of Rochester Medical Center, 265 Crittenden Blvd, Box 655c, Rochester, NY 14620, USA.
University of Rochester Medical Center, 265 Crittenden Blvd, Box 655c, Rochester, NY 14620, USA.
J Affect Disord. 2019 Feb 15;245:484-487. doi: 10.1016/j.jad.2018.11.069. Epub 2018 Nov 5.
Middle and late life adults may present depression symptomology differently than the expected symptoms of depression. Clusters of common symptoms may be overlooked when determining the most appropriate treatment options, leading to a less than effective treatment. Investigation of these clusters is needed to better understand patterns of depressive symptomology among middle and late life adults.
Consent, demographics, self-report items and PHQ-9 items were administered to subjects. Latent class analysis (LCA), was used to determine groupings of patients based on PHQ-9 items. Demographics were compared across classes for additional information.
A total of 252 subjects aged 45-85 years old were enrolled. An LCA indicated that a 3 class solution explained the clusters endorsed: Low Concerns (35%), Many Concerns (34%), and Sleep and Fatigue Concerns (31%). Patients in the Low Concerns class were more likely to have private insurance compared to those in the Many Concerns class (57% vs 34%, p = 0.003). They also reported better general health (M = 2.39 vs M = 1.58, p < 0.001), and visited their PCP less frequently (M = 1.64 visits vs M = 3.31 visits, p = 0.004).
Recall bias may have been present due to self-report of symptoms which was a report based on a low threshold for endorsement of items. Future larger studies should utilize more response options.
LCA suggests there are three unique groupings of symptoms as reported by the PHQ-9. These clusters may be valuable in determining treatment options and designing interventions.
中年和老年患者的抑郁症状表现可能与预期的抑郁症状不同。在确定最合适的治疗方案时,可能会忽略常见症状群,从而导致治疗效果不佳。因此,需要研究这些症状群,以更好地了解中年和老年患者的抑郁症状模式。
向受试者提供同意书、人口统计学资料、自我报告项目和 PHQ-9 项目。使用潜在类别分析(LCA)根据 PHQ-9 项目确定患者的分组。对各分类进行人口统计学比较,以获取更多信息。
共纳入 252 名年龄在 45-85 岁的受试者。LCA 表明,3 类解决方案可以解释患者的分组:轻度关注(35%)、高度关注(34%)和睡眠与疲劳关注(31%)。与高度关注组相比,低度关注组患者更有可能拥有私人保险(57%比 34%,p=0.003)。他们的一般健康状况也更好(M=2.39 比 M=1.58,p<0.001),并且就诊于他们的初级保健医生的频率也较低(M=1.64 次就诊比 M=3.31 次就诊,p=0.004)。
由于症状是根据对项目的低度认可进行的自我报告,因此可能存在回忆偏倚。未来的更大规模研究应使用更多的反应选项。
LCA 表明,PHQ-9 报告的症状存在三种独特的分组。这些聚类在确定治疗方案和设计干预措施方面可能具有重要价值。