Department of Pediatrics, Kansai Medical University, Hirakata 573-1010, Japan.
Nutrients. 2018 Nov 13;10(11):1745. doi: 10.3390/nu10111745.
Calcium (Ca) plays an important role in the pathogenesis of insulin resistance syndrome. Osteocalcin (OC), a bone formation biomarker, acts directly on β-cells and increases insulin secretion. We determined the effects of Ca deficiency during pregnancy and/or lactation on insulin resistance in offspring. Female Wistar rats consumed either a Ca-deficient or control diet ad libitum from three weeks preconception to 21 days postparturition. Pups were allowed to nurse their original mothers until weaning. The offspring were fed a control diet beginning at weaning and were killed on day 180. Serum carboxylated OC (Gla-OC) and undercarboxylated OC (Glu-OC), insulin and adipokines in offspring were measured. In males, mean levels of insulin, glucose, and HOMA-IR were higher in the Ca-deficient group than in the control group. In addition, ionized Ca (iCa) was inversely associated with serum Glu-OC and adiponectin in males. In females, mean levels of Glu-OC and Gla-OC in the Ca-deficient group were higher than in the control group. In all offspring, serum leptin levels were correlated with serum insulin levels, and inversely correlated with iCa. In conclusion, maternal Ca restriction during pregnancy and/or lactation influences postnatal offspring Ca metabolism and insulin resistance in a sex-specific manner.
钙（Ca）在胰岛素抵抗综合征的发病机制中起重要作用。骨钙素（OC）是一种骨形成生物标志物，它直接作用于β细胞并增加胰岛素分泌。我们确定了妊娠和/或哺乳期 Ca 缺乏对后代胰岛素抵抗的影响。雌性 Wistar 大鼠从受孕前 3 周至分娩后 21 天自由摄取 Ca 缺乏或对照饮食。让幼崽继续母乳喂养其亲生母亲，直到断奶。从断奶开始，后代喂食对照饮食，并在第 180 天处死。测量后代血清羧化 OC（Gla-OC）和未羧化 OC（Glu-OC）、胰岛素和脂肪因子的水平。在雄性中，Ca 缺乏组的胰岛素、葡萄糖和 HOMA-IR 平均水平高于对照组。此外，离子化 Ca（iCa）与雄性血清 Glu-OC 和脂联素呈负相关。在雌性中，Ca 缺乏组的 Glu-OC 和 Gla-OC 平均水平高于对照组。所有后代的血清瘦素水平与血清胰岛素水平相关，与 iCa 呈负相关。总之，妊娠和/或哺乳期母体 Ca 限制以性别特异性方式影响后代产后 Ca 代谢和胰岛素抵抗。
