年龄、性别以及遗传和环境因素对青少年及成年双胞胎意外伤害的影响
Age, Sex, and Genetic and Environmental Effects on Unintentional Injuries in Young and Adult Twins.
作者信息
Salminen Simo, Vuoksimaa Eero, Rose Richard J, Kaprio Jaakko
机构信息
Department of Social Psychology,University of Helsinki,Helsinki,Finland.
Institute for Molecular Medicine Finland (FIMM) & Department of Public Health,University of Helsinki,Helsinki,Finland.
出版信息
Twin Res Hum Genet. 2018 Dec;21(6):502-506. doi: 10.1017/thg.2018.61. Epub 2018 Nov 15.
The aim of this study was to examine the effects of genetic and environment influences and sex on injury involvement using two sets of Finnish twin data. The younger participants were 955 twins born between 1983 and 1987, aged 20 to 24 years. The older participants were 12,428 twins born between 1930 and 1957, aged 33 to 60 years. Within-twin correlations in monozygotic and dizygotic twins suggested that genetic effects play no role in injury involvement among young twins, but do have some effect at older ages. The results indicated that environmental factors have greater importance in injury involvement than genetic factors in the younger twin data set (FT12), whereas in a middle-aged (33-60 years) twin data set, genetic effects explained about quarter of the variance in injury involvement. Sex was a strong contributing factor, with males being generally more prone to injuries than females.
本研究的目的是利用两组芬兰双胞胎数据，检验基因和环境影响以及性别对受伤情况的作用。较年轻的参与者是1983年至1987年出生的955对双胞胎，年龄在20至24岁之间。较年长的参与者是1930年至1957年出生的12428对双胞胎，年龄在33至60岁之间。同卵双胞胎和异卵双胞胎之间的双胞胎内相关性表明，基因效应在年轻双胞胎的受伤情况中不起作用，但在年长时确实有一定影响。结果表明，在较年轻的双胞胎数据集（FT12）中，环境因素在受伤情况中比基因因素更为重要，而在中年（33至60岁）双胞胎数据集中，基因效应解释了受伤情况中约四分之一的方差。性别是一个重要因素，男性通常比女性更容易受伤。
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