Pytasz M, Dec R
Acta Physiol Pol. 1977 Sep-Oct;28(5):453-62.
The activity of acetylcholinesterase (AChE 3.1.1.7.) was determined in skeletal muscle homogenates in frogs at various time intervals (15--24 days) after denervation. At the same time changes in AChE activity were compared with morphological changes of neuromuscular end plates in these muscles. Muscle denervation caused initially, within 30 hours, a rise in AChE activity by about 30% in relation to control muscles, followed by its fall to the control values after 4--6 days. The activity decreased further reaching lowest values 15 days after denervation, when it amounted to about 65% of the value of control muscles. After that time, when regeneration of nerves set in, the activity of AChe rose again returning to the control values after 24 hours. In the initial period of denervation no correlation was found between AChE activity and morphological changes in end plates. It was found however in the later period when degenerative changes were most pronounced as well as when reinnervation was in progress.
在去神经后的不同时间间隔（15 - 24天）测定青蛙骨骼肌匀浆中乙酰胆碱酯酶（AChE 3.1.1.7.）的活性。同时，将这些肌肉中AChE活性的变化与神经肌肉终板的形态变化进行比较。肌肉去神经最初在30小时内使AChE活性相对于对照肌肉升高约30%，随后在4 - 6天后降至对照值。活性进一步下降，在去神经15天后达到最低值，此时约为对照肌肉值的65%。此后，当神经开始再生时，AChE活性再次升高，24小时后恢复到对照值。在去神经的初期，未发现AChE活性与终板形态变化之间存在相关性。然而，在后期，当退行性变化最为明显以及再支配进行时发现了这种相关性。
