Ibrahim Ezzeldin Saleh
Department of Anaesthesia and Intensive Care, Faculty of Medicine, Menoufia University, Shebeen El-Kom, Egypt.
Saudi J Anaesth. 2018 Oct-Dec;12(4):529-534. doi: 10.4103/sja.SJA_50_18.
The present study was done to investigate the effect of the enteral omega-3 fatty acids on critically ill septic patients.
A total of 110 critically ill septic patients were divided into two groups, 55 patients in each. Group A received enteral nutrition with 1000 mg omega-3 three times daily and Group B received enteral nutrition without omega-3. Demographic data, sepsis characteristics, number of patients required invasive ventilation, ventilation days, Intensive Care Unit (ICU) sequential organ failure assessment (SOFA) score, organ failure-free days, hemodynamic failure-free days, ICU stay, ICU, and hospital outcome were recorded.
Leukocytic count and C-reactive protein were higher in Group B during ICU stay ( = 0.010 and 0.003, respectively). The number of organ and hemodynamic failure-free days was higher in Group A ( < 0.05). Overall, ICU SOFA score was higher in Group B ( = 0.03). There was no difference in the number of patients requiring mechanical ventilation ( = 0.41). ICU stay was longer in Group B ( = 0.019); however, post-ICU hospital stay was similar in both groups. There were no differences regarding ICU and hospital survivors ( > 0.05).
Enteral nutrition with omega-3 can improve organ function and decrease ICU stay in septic patients. Omega-3 fatty acids do not affect ICU mortality or decrease the post-ICU hospital stay.
本研究旨在探讨肠内ω-3脂肪酸对重症脓毒症患者的影响。
总共110例重症脓毒症患者被分为两组，每组55例。A组患者每天三次接受含1000毫克ω-3的肠内营养，B组患者接受不含ω-3的肠内营养。记录人口统计学数据、脓毒症特征、需要有创通气的患者数量、通气天数、重症监护病房（ICU）序贯器官衰竭评估（SOFA）评分、无器官衰竭天数、无血流动力学衰竭天数、ICU住院时间、ICU及医院结局。
在ICU住院期间，B组的白细胞计数和C反应蛋白更高（分别为P = 0.010和0.003）。A组的无器官和无血流动力学衰竭天数更多（P < 0.05）。总体而言，B组的ICU SOFA评分更高（P = 0.03）。需要机械通气的患者数量没有差异（P = 0.41）。B组的ICU住院时间更长（P = 0.019）；然而，两组的ICU后住院时间相似。关于ICU和医院幸存者没有差异（P > 0.05）。
含ω-3的肠内营养可改善脓毒症患者的器官功能并缩短ICU住院时间。ω-3脂肪酸不影响ICU死亡率或缩短ICU后住院时间。
