Molecular Science Laboratory, National Institute of Immunology, New Delhi, India.
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.
Front Immunol. 2018 Oct 31;9:2508. doi: 10.3389/fimmu.2018.02508. eCollection 2018.
Th17-lymphocytes are well known for their deleterious role in autoimmunity. But does the notoriety of this repertoire extend beyond autoimmunity? In the present study we employed experimental autoimmune encephalomyelitis as model system to study the role auto-reactive Th17 cells in neuropsychiatric disorders. The mice with experimental autoimmune encephalomyelitis exhibited exaggerated grooming activity. The observed behavioral anomaly resembled obsessive compulsive disorder (OCD) upon analysis of grooming microstructure, induced grooming, marble burying and nestlet shredding. The observed OCD like behavior was relieved upon Th17 cell depletion; alternatively, it could alone be induced by adoptive transfer of myelin oligodendrocyte glycoprotein (35-55) reactive Th17 in mice. The observed OCD like behavior was also alleviated upon treatment with a selective serotonin reuptake inhibitor, fluoxetine.
Th17 淋巴细胞以其在自身免疫中的有害作用而闻名。但是这种免疫谱的恶名是否超出了自身免疫的范围呢？在本研究中，我们采用实验性自身免疫性脑脊髓炎作为模型系统，研究自身反应性 Th17 细胞在神经精神疾病中的作用。患有实验性自身免疫性脑脊髓炎的小鼠表现出过度的梳理行为。通过分析梳理的微观结构、诱导梳理、埋丸和撕碎巢穴，观察到的行为异常类似于强迫症（OCD）。Th17 细胞耗竭后，观察到的 OCD 样行为得到缓解；或者，它可以单独通过在 小鼠中过继转移髓鞘少突胶质细胞糖蛋白（35-55）反应性 Th17 细胞来诱导。观察到的 OCD 样行为也可以通过选择性 5-羟色胺再摄取抑制剂氟西汀来缓解。
