may be an initiating factor in newly diagnosed ulcerative colitis patients: A pilot study.

AIM

To directly visualize () by the highly sensitive and specific technique of immunohistochemical staining in colonic tissue from patients newly diagnosed with ulcerative colitis (UC).

METHODS

Colonoscopic biopsies from thirty patients with newly diagnosed UC and thirty controls were stained with Giemsa stain and immunohistochemical stain for detection of in the colonic tissue. Results were confirmed by testing Ag in the stool then infected patients were randomized to receive either anti treatment or placebo.

RESULTS

Twelve/30 (40%) of the UC patients were positive for by Giemsa, and 17/30 (56.6%) by immunohistochemistry stain. Among the control group 4/30 (13.3%) and 6/30 (20 %) were positive for by Giemsa and immunohistochemistry staining respectively. was significantly higher in UC than in controls ( = 0.04 and 0.007). All Giemsa positive patients and controls were positive by immunohistochemical stain. Four cases of the control group positive for also showed microscopic features consistent with early UC.

CONCLUSION

can be detected in colonic mucosa of patients with UC and patients with histological superficial ulcerations and mild infiltration consistent with early UC. There seems to be an association between UC and presence of in the colonic tissue. Whether this is a causal relationship or not remains to be discovered.