Wu Xiao-Wei, Ji Hong-Zan, Yang Miao-Fang, Wu Lin, Wang Fang-Yu
Xiao-Wei Wu, Hong-Zan Ji, Miao-Fang Yang, Lin Wu, Fang-Yu Wang, Department of Gastroenterology and Hepatology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu Province, China.
World J Gastroenterol. 2015 Apr 21;21(15):4750-6. doi: 10.3748/wjg.v21.i15.4750.
To investigate the relationship between Helicobacter pylori infection and inflammatory bowel disease (IBD) in an Asian population.
The PubMed, EMBASE, and Cochrane Library databases were searched for observational studies published up until June 2014, without language restrictions. Additional references were obtained from reviewed articles.
Ten studies involving 1299 IBD patients and 1817 controls were included in the meta-analysis (24.9% of IBD patients had H. pylori infection vs 48.3% of the controls). The pooled risk ratio for H. pylori infection in IBD patients compared with controls was 0.48 (95%CI: 0.43-0.54; P < 0.001). There was no significant heterogeneity in the included studies (I (2) = 21%). Egger's linear regression indicated that there was no significant publication bias (P = 0.203).
The H. pylori infection rate in Asian IBD patients is significantly lower than in non-IBD patients, indicating that infection protects against the development of IBD.
在亚洲人群中研究幽门螺杆菌感染与炎症性肠病（IBD）之间的关系。
检索PubMed、EMBASE和Cochrane图书馆数据库，查找截至2014年6月发表的观察性研究，无语言限制。从综述文章中获取其他参考文献。
荟萃分析纳入了10项研究，涉及1299例IBD患者和1817例对照（24.9%的IBD患者有幽门螺杆菌感染，而对照为48.3%）。IBD患者与对照相比，幽门螺杆菌感染的合并风险比为0.48（95%CI：0.43 - 0.54；P < 0.001）。纳入研究中无显著异质性（I² = 21%）。Egger线性回归表明无显著发表偏倚（P = 0.203）。
亚洲IBD患者的幽门螺杆菌感染率显著低于非IBD患者，表明感染可预防IBD的发生。
