Graham P C, Lindop G B
University Department of Pathology, Western Infirmary, Glasgow, Scotland, United Kingdom.
Kidney Int. 1988 Jun;33(6):1084-90. doi: 10.1038/ki.1988.115.
We used a human renin antiserum and an immunoperoxidase method to investigate the distribution of renin-containing cells in 19 adult polycystic kidneys: 9 autopsy and 10 nephrectomy cases. These cells were present in residual normal kidney, in scarred renal parenchyma and in area of fibrous tissue. They were situated mainly in juxtaglomerular apparatuses (JGAs) and in the walls of arteries and arterioles. A semi-quantitative analysis showed hyperplasia of JGA renin-containing cells in the untreated autopsy cases. In both groups there was an abnormal distribution of renin-containing cells; only 50% were located in the JGAs the remainder were mainly in the walls of small arteries. These were often thin, attenuated vessels in the walls of cysts. Cells containing renin were also found isolated in fibrous tissue separate from the arterial tree. This abnormal location of the renin-containing cells suggests that they may respond to different stimuli than those in normal kidneys, and their abnormal distribution could affect both the intrarenal action of renin and also its release into the blood.
我们使用人肾素抗血清和免疫过氧化物酶方法，研究了19例成人多囊肾中含肾素细胞的分布情况，其中9例为尸检病例，10例为肾切除病例。这些细胞存在于残留的正常肾组织、瘢痕化的肾实质以及纤维组织区域。它们主要位于肾小球旁器（JGAs）以及动脉和小动脉壁中。半定量分析显示，未经治疗的尸检病例中肾小球旁器含肾素细胞增生。在两组中，含肾素细胞均存在异常分布；只有50%位于肾小球旁器，其余主要位于小动脉壁。这些小动脉在囊肿壁中往往很细且变细。含肾素的细胞也被发现孤立于与动脉树分离的纤维组织中。含肾素细胞的这种异常位置表明，它们可能对与正常肾脏不同的刺激作出反应，并且它们的异常分布可能会影响肾素在肾内的作用及其释放到血液中的过程。
