Department of Psychiatry, St. Antonius Hospital, Nieuwegein, The Netherlands.
University Centre of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.
Aging Ment Health. 2020 Jan;24(1):49-55. doi: 10.1080/13607863.2018.1515885. Epub 2018 Nov 15.
To study the association between vitamin D levels and frailty, its components and course in a depressed sample. Baseline and two-year follow-up data from the depressed sample of the Netherlands Study of Depression in Older persons (NESDO), a prospective observational cohort study, were analyzed. The 378 participants (aged 60-93) had a diagnosis of depression according to DSM-IV criteria. Frailty was defined according to Fried's physical phenotype. 25-OH vitamin D measurement was performed by liquid chromatography - tandem mass spectrometry. Linear and logistic regression analyses were performed, adjusted for covariates. Higher vitamin D levels were cross-sectionally associated with lower prevalence of frailty (OR 0.64 [95%-CI 0.45 - 0.90], = .010), predicted a lower incidence of frailty among non-frail depressed patients (OR 0.51 [95%-CI 0.26 - 1.00], =.050), and, surprisingly, the persistence of frailty among frail depressed patients (OR 2.82 [95%-CI 1.23 - 6.49], =.015). In a depressed population, higher vitamin D levels were associated with lower prevalence and incidence of frailty. Future studies should examine whether the favorable effect of low vitamin D levels on the course of frailty can be explained by confounding or whether unknown pathophysiological mechanisms may exert protective effects.
研究维生素 D 水平与衰弱及其各组成部分和病程在抑郁人群中的关联。对荷兰老年人抑郁研究（NESDO）抑郁人群的基线和两年随访数据进行了分析。该前瞻性观察队列研究纳入了 378 名（年龄 60-93 岁）符合 DSM-IV 标准的抑郁诊断的参与者。衰弱根据 Fried 的身体表型进行定义。25-羟维生素 D 测量通过液相色谱-串联质谱法进行。进行了线性和逻辑回归分析，并对协变量进行了调整。较高的维生素 D 水平与衰弱的患病率较低呈横断面相关（OR 0.64 [95%-CI 0.45 - 0.90]，.010），在非衰弱的抑郁患者中，较低的维生素 D 水平预测衰弱的发生率较低（OR 0.51 [95%-CI 0.26 - 1.00]，.050），并且在衰弱的抑郁患者中，衰弱的持续时间更长（OR 2.82 [95%-CI 1.23 - 6.49]，.015）。在抑郁人群中，较高的维生素 D 水平与衰弱的患病率和发生率较低有关。未来的研究应检查低维生素 D 水平对衰弱病程的有利影响是否可以用混杂因素来解释，或者是否存在未知的病理生理机制可能发挥保护作用。
