Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
BMC Geriatr. 2020 Apr 6;20(1):126. doi: 10.1186/s12877-020-01523-w.
Vitamin D deficiency has been linked to the risk of frailty. However, there are limited methods for evaluations of the potential association of vitamin D with frailty in a longevous (80+) population. The aim of this study was to examine the association between plasma 25-hydroxyvitamin D [25(OH)D] levels and the risk of frailty among the Chinese community based oldest-old.
Secondary analysis of data compiled in the 2011 wave of the Chinese Longitudinal Healthy Longevity Survey (n = 1324) was performed. Frailty was assessed by the Study of Osteoporotic Fractures (SOF) index. Multivariate logistic regression and spline smoothing with threshold effect analysis were performed to investigate the association between 25(OH) D level and the risk of frailty after adjusting for socio-demographic variables, health characteristics and confounding biomarkers.
The mean age was 92.89 ± 7.92 years, and 844 (63.7%) participants were women. In all, data from 426 (33.2, 95% confidence interval, CI: 29.66-34.69) frail participants were recorded. After adjustment for confounding covariates, the level of 25(OH) D was significantly related to frailty. By spline smoothing with threshold effect analysis, a monotonically negative association between 25(OH) D and frailty was identified. Subgroup analyses revealed that the association did not differ by sex or age.
The 25(OH) D level was inversely associated with the risk of frailty among the Chinese community-based oldest-old.
维生素 D 缺乏与虚弱风险有关。然而，在长寿（80 岁以上）人群中，评估维生素 D 与虚弱潜在关联的方法有限。本研究旨在研究血浆 25-羟维生素 D [25(OH)D]水平与中国社区最年长人群虚弱风险之间的关系。
对中国长寿纵向研究 2011 年波次的数据进行二次分析（n=1324）。采用骨质疏松性骨折研究（SOF）指数评估虚弱。在调整社会人口统计学变量、健康特征和混杂生物标志物后，采用多元逻辑回归和带有阈值效应分析的样条平滑法来研究 25(OH)D 水平与虚弱风险之间的关系。
平均年龄为 92.89±7.92 岁，844 名（63.7%）参与者为女性。共记录了 426 名（33.2%，95%置信区间：29.66-34.69）虚弱参与者的数据。在调整混杂协变量后，25(OH)D 水平与虚弱明显相关。通过带有阈值效应分析的样条平滑法，发现 25(OH)D 与虚弱之间呈单调负相关。亚组分析显示，这种关联不受性别或年龄的影响。
在中国社区最年长人群中，25(OH)D 水平与虚弱风险呈负相关。
