一种用于次氯酸的荧光探针，具有比色和荧光特性，并可在活细胞中成像。
A fluorescent probe for hypochlorite with colorimetric and fluorometric characteristics and imaging in living cells.
机构信息
Guangxi Colleges and Universities Key Laboratory of Food Safety and Detection, Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, Guangxi, 541004, PR China.
Guangxi Colleges and Universities Key Laboratory of Food Safety and Detection, Guangxi Key Laboratory of Electrochemical and Magnetochemical Functional Materials, College of Chemistry and Bioengineering, Guilin University of Technology, Guilin, Guangxi, 541004, PR China.
出版信息
Anal Biochem. 2019 Feb 1;566:32-36. doi: 10.1016/j.ab.2018.11.011. Epub 2018 Nov 12.
An excellent fluorescent probe with "turn on" phenomenon for sensitive monitoring hypochlorite (ClO) was prepared using the mild condensation reaction between coumarin and hydroxylamine (NHOH). The probe possessed potent selectivity to ClO with obvious color changes from yellow to light yellow and green to blue fluorescence emission, which could be noticed by the naked eye. Moreover, the probe has been succeeded in imaging ClO in living A549 cells and thus has the potential prospect in the visual detection of intracellular ClO.
一种具有“开启”现象的用于灵敏监测次氯酸根（ClO）的优良荧光探针，是通过香豆素与羟胺（NHOH）之间的温和缩合反应制备的。该探针对 ClO 具有很强的选择性，其颜色从黄色变为浅黄色，荧光发射从绿色变为蓝色，肉眼可观察到明显的变化。此外，该探针已成功用于活 A549 细胞中 ClO 的成像，因此在细胞内 ClO 的可视化检测方面具有潜在的前景。
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