Schwendemann G
Neurologische Universitätsklinik Essen.
Z Hautkr. 1988 May 15;63(5):357-65.
Clinical symptoms of the central and peripheral nervous system occur in about 40% of patients wit HIV infection. At autopsy, CNS lesions can be demonstrated in even higher percentages. Primary sequelae of HIV infection--either due to direct viral effects or the immunopathologic response of the human host--are acute aseptic meningitis or mengingo-encephalitis, HIV encephalopathy, myelopathy, neuropathy, and myositis. Secondary consequences of immunodeficiency in AIDS are opportunistic infections with other viruses, bacteria, fungi, and protozoa, e.g. CMV, HSV and HZV encephalitis, mycobacterial CNS infections, neurosyphilis, cryptococcal meningitis, and last but not least cerebral toxoplasmosis. The main secondary malignoma of the CNS is lymphoma. Together these disorders form a complex spectrum of central and peripheral neurological symptoms.
约40%的HIV感染患者会出现中枢和周围神经系统的临床症状。尸检时,中枢神经系统病变的比例甚至更高。HIV感染的主要后遗症——无论是由于病毒的直接作用还是人类宿主的免疫病理反应——是急性无菌性脑膜炎或脑膜脑炎、HIV脑病、脊髓病、神经病变和肌炎。艾滋病免疫缺陷的次要后果是感染其他病毒、细菌、真菌和原生动物,如巨细胞病毒、单纯疱疹病毒和带状疱疹病毒引起的脑炎、分枝杆菌中枢神经系统感染、神经梅毒、隐球菌性脑膜炎,以及最常见的脑弓形虫病。中枢神经系统的主要继发性恶性肿瘤是淋巴瘤。这些疾病共同构成了中枢和周围神经症状的复杂谱系。