帕金森病和肌张力障碍的苍白球β爆发。
Pallidal beta bursts in Parkinson's disease and dystonia.
机构信息
Movement Disorders and Neuromodulation Unit, Department of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Department of Neurosurgery, Medical School Hannover, Hannover, Germany.
出版信息
Mov Disord. 2019 Mar;34(3):420-424. doi: 10.1002/mds.27524. Epub 2018 Nov 15.
BACKGROUND
Exaggerated beta power has been discussed as a disease-specific biomarker for Parkinson's disease (PD) and has recently been suggested to rely on prolonged bursts of subthalamic beta synchronization.
OBJECTIVE
In this study, we test whether prolonged bursts are disease specific for beta activity in PD by comparison to oscillatory activity in dystonia.
METHODS
Pallidal local field potentials were recorded from 5 PD patients ON and OFF dopaminergic medication and 5 dystonia patients. Synchronization of beta and low-frequency oscillations in bursts was compared between groups with respect to their duration, amplitude, and rate.
RESULTS
Pallidal beta bursts were longer in PD-OFF than PD-ON or dystonia (P < .05). PD-ON and dystonia displayed similar beta burst dynamics. Low-frequency burst features showed no differences across groups.
CONCLUSIONS
Prolonged burst duration appears as a disease-specific feature for beta activity in PD across the basal ganglia. With dopaminergic medication, beta bursts in PD resemble those in dystonia, which supports the notion of short beta bursts as a physiological pattern. © 2018 International Parkinson and Movement Disorder Society.
背景
过度的β波功率已被讨论为帕金森病（PD）的特异性生物标志物，并且最近有人提出，β波同步的丘脑下核延长爆发依赖于β波的延长爆发。
目的
在这项研究中，我们通过与肌张力障碍的振荡活动进行比较，来测试β活动的延长爆发是否是 PD 的特异性疾病。
方法
从 5 名 PD 患者（服用多巴胺药物和不服用多巴胺药物）和 5 名肌张力障碍患者的苍白球记录局部场电位。比较各组之间β和低频振荡在爆发时的同步性，包括持续时间、振幅和频率。
结果
PD-OFF 的苍白球β爆发持续时间长于 PD-ON 或肌张力障碍（P<.05）。PD-ON 和肌张力障碍显示出相似的β爆发动力学。低频爆发特征在各组之间没有差异。
结论
在整个基底神经节中，延长的爆发持续时间似乎是 PD 中β活动的特异性特征。在服用多巴胺药物时，PD 中的β爆发类似于肌张力障碍，这支持了β爆发短暂作为一种生理模式的观点。
Zotero 插件