Shi Lin, Xu Yichen, Fan Shiying, Yin Zixiao, Qin Guofan, Zhang Jianguo, Yang Anchao
Department of Functional Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.
NPJ Parkinsons Dis. 2025 May 5;11(1):109. doi: 10.1038/s41531-025-00947-8.
Parkinson's disease (PD) is associated with disrupted neural activity in the substantia nigra, but its electrophysiological changes remain underexplored. This study investigates the oscillatory patterns of substantia nigra pars reticulata (SNr) in PD, compared to dystonia (DT). Intraoperative recordings of the SNr were obtained from 20 PD and 16 DT patients during DBS surgery. Spectral power, neuronal firing rate, beta burst dynamics, and correlation analysis of the SNr signal were analyzed. PD patients exhibited increased alpha and beta power, elevated firing rates, and reduced aperiodic exponent values in SNr compared to DT. PD beta bursts showed prolonged durations and fewer short bursts. Beta power negatively correlated with motor symptom improvement rates in PD but not in DT patients. These findings highlight pathological beta power in SNr of PD, which indicates that SNr-DBS may offer a future therapeutic avenue for PD.
帕金森病（PD）与黑质神经活动紊乱有关，但其电生理变化仍未得到充分研究。本研究调查了与肌张力障碍（DT）相比，帕金森病中黑质网状部（SNr）的振荡模式。在脑深部电刺激（DBS）手术期间，从20例帕金森病患者和16例肌张力障碍患者中获取了黑质网状部的术中记录。分析了黑质网状部信号的频谱功率、神经元放电率、β爆发动力学和相关性分析。与肌张力障碍患者相比，帕金森病患者黑质网状部的α和β功率增加、放电率升高且非周期性指数值降低。帕金森病的β爆发持续时间延长且短爆发较少。β功率与帕金森病患者的运动症状改善率呈负相关，但与肌张力障碍患者无关。这些发现突出了帕金森病黑质网状部的病理性β功率，这表明黑质网状部脑深部电刺激可能为帕金森病提供未来的治疗途径。
