He P H, Min Y L, Zhou C M, Tong X Y, Lin X, Li Q, Zha Y
Renal Division, Department of Medicine, Guizhou Provincial People's Hospital, Guiyang 550002, China.
Department of Nephrology, First People's Hospital of Guiyang, Guiyang 550002, China.
Zhonghua Yi Xue Za Zhi. 2018 Nov 13;98(42):3411-3414. doi: 10.3760/cma.j.issn.0376-2491.2018.42.007.
To evaluate the relationship between surrogate markers of visceral obesity[hypertriglyceridemic waist (HW) phenotype, visceral adiposity index (VAL), lipid accumulation product (LAP)]and atherosclerosis in hemodialysis patients. A multi-center cross-sectional study was carried out. A total of 961 maintenance hemodialysis (MHD) patients from 11 hemodialysis centers of Guizhou province between July 2016 and September 2017 were enrolled in the study. Anthropometric measures were performed in all subjects. Laboratory parameters including triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein-cholesterol were extracted from the medical records by researchers. Pearson correlation analysis was used to investigate the correlation between HW phenotype, VAI, LAP and plasma atherosclerotic index (AIP). Multivariate linear regression analysis was used to evaluate factors affecting AIP. Totally, 585 men and 376 women aged 18-90 years, with a mean age of (56.08±15.42) years were recruited in the study. Pearson correlation analysis showed that VAI (men: =0.82, women: =0.84), LAP (men: =0.73, women: =0.74) and having HW phenotype (men: =0.62, women: =0.63) correlated positively with AIP (all <0.001). Multivariate linear regression analysis showed that VAI (men: β=0.77, women: β=0.82) and LAP (men: β=0.73, women: β=0.73) were independent associated factors of AIP after adjustment of BMI, age, smoking and history of diabetes and hypertension (all <0.001). Surrogate markers of visceral obesity such as having HW phenotype, VAI, LAP correlated positively with AIP. VAI, LAP has positive impacts on AIP independent of BMI, age, smoking and other traditional atherosclerosis risk factors.
评估内脏肥胖替代指标[高甘油三酯腰围（HW）表型、内脏脂肪指数（VAL）、脂质蓄积产物（LAP）]与血液透析患者动脉粥样硬化之间的关系。开展了一项多中心横断面研究。2016年7月至2017年9月期间，来自贵州省11个血液透析中心的961例维持性血液透析（MHD）患者纳入本研究。对所有受试者进行人体测量。研究人员从病历中提取包括甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇在内的实验室参数。采用Pearson相关分析研究HW表型、VAI、LAP与血浆动脉粥样硬化指数（AIP）之间的相关性。采用多元线性回归分析评估影响AIP的因素。本研究共纳入585例男性和376例女性，年龄18 - 90岁，平均年龄（56.08±15.42）岁。Pearson相关分析显示，VAI（男性：r = 0.82，女性：r = 0.84）、LAP（男性：r = 0.73，女性：r = 0.74）以及具有HW表型（男性：r = 0.62，女性：r = 0.63）均与AIP呈正相关（均P < 0.001）。多元线性回归分析显示，在校正BMI、年龄、吸烟以及糖尿病和高血压病史后，VAI（男性：β = 0.77，女性：β = 0.82）和LAP（男性：β = 0.73，女性：β = 0.73）是AIP的独立相关因素（均P < 0.001）。内脏肥胖替代指标如具有HW表型、VAI、LAP与AIP呈正相关。VAI、LAP对AIP有正向影响，独立于BMI、年龄、吸烟及其他传统动脉粥样硬化危险因素。
