Qiu Hao, Wang Xianping, Choi Anthony, Xie Fei, Zhao Wenbing
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1-4. doi: 10.1109/EMBC.2018.8513372.
Ultrashort, high-intensity electric pulses open nanopores in biological cell membranes. Ion transport in nanopore is analyzed using a numerical method that couples the Nernst-Planck equations for ionic concentrations, the Poisson equation for the electric potential, and Navier-Stokes equations for the fluid flow. Roles of the applied bias, pore size, as well as the surface charge lining the membrane are comprehensively examined through I-V characteristics, conductance variations of the pore. Our results show that the surface charge distribution has an impact on the ionic conduction due to mutual electrostatic force interference. In addition, a larger pore would conduct a larger ionic current thus being more conductive on the condition of the same bias applied, which would suggest a bias-dependent expansion of pores.
超短高强度电脉冲可在生物细胞膜上打开纳米孔。利用一种数值方法分析纳米孔中的离子传输，该方法将离子浓度的能斯特-普朗克方程、电势的泊松方程以及流体流动的纳维-斯托克斯方程耦合在一起。通过电流-电压特性、孔的电导变化，全面研究了外加偏压、孔径以及膜表面电荷的作用。我们的结果表明，由于相互的静电力干扰，表面电荷分布会对离子传导产生影响。此外，在施加相同偏压的情况下，较大的孔会传导更大的离子电流，因此导电性更强，这表明孔的大小与偏压有关。
