Hu Mengjiao, Ji Fang, Lu Zhongkang, Huang Weimin, Khosrowabadi Reza, Zhao Ling, Ang Kai Keng, Phua Kok Soon, Nasrallah Fatima Ali, Chuang Kai-Hsiang, Stephenson Mary C, Totman John, Jiang Xudong, Chew Effie, Guan Cuntai, Zhou Juan
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1050-1053. doi: 10.1109/EMBC.2018.8512395.
Mapping the brain alterations post stroke and post intervention is important for rehabilitation therapy development. Previous work has shown changes in functional connectivity based on resting-state fMRI, structural connectivity derived from diffusion MRI and perfusion as a result of brain-computer interface-assisted motor imagery (MI-BCI) and transcranial direct current stimulation (tDCS) in upper-limb stroke rehabilitation. Besides functional connectivity, regional amplitude of local low-frequency fluctuations (ALFF) may provide complementary information on the underlying neural mechanism in disease. Yet, findings on spontaneous brain activity during resting-state in stroke patients after intervention are limited and inconsistent. Here, we sought to investigate the different brain alteration patterns induced by tDCS compared to MI-BCI for upper-limb rehabilitation in chronic stroke patients using resting-state fMRI-based ALFF method. Our results suggested that stroke patients have lower ALFF in the ipsilesional somatomotor network compared to controls at baseline. Increased ALFF at contralesional somatomotor network and alterations in higher-level cognitive networks such as the default mode network (DMN) and salience networks accompany motor recovery after intervention; though the MI-BCI alone group and MI-BCI combined with tDCS group exhibit differential patterns.
绘制中风后及干预后的大脑变化图对于康复治疗的发展至关重要。先前的研究表明，基于静息态功能磁共振成像（fMRI）的功能连接性、源自扩散磁共振成像的结构连接性以及因脑机接口辅助运动想象（MI-BCI）和经颅直流电刺激（tDCS）在上肢中风康复中导致的灌注发生了变化。除了功能连接性，局部低频波动的区域振幅（ALFF）可能会为疾病潜在的神经机制提供补充信息。然而，关于干预后中风患者静息态期间自发脑活动的研究结果有限且不一致。在此，我们试图使用基于静息态fMRI的ALFF方法，研究与MI-BCI相比，tDCS在上肢慢性中风患者康复中所诱导的不同大脑变化模式。我们的结果表明，在基线时，与对照组相比，中风患者患侧躯体运动网络的ALFF较低。干预后，对侧躯体运动网络的ALFF增加以及诸如默认模式网络（DMN）和突显网络等高阶认知网络发生改变伴随着运动恢复；尽管单独使用MI-BCI组和MI-BCI联合tDCS组表现出不同的模式。
