Majerus Steve J A, Knauss Thomas, Mandal Soumyajit, Vince Geoff, Damaser Margot S
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:1416-1419. doi: 10.1109/EMBC.2018.8512588.
Subjective analysis of bruits has long been an element of vascular access physical exams. Digital recordings of blood flow bruits-phonoangiograms (PAGs)-may provide an objective, non-imaging measure of vascular access stenosis. We have analyzed the long-term stability in PAGs from typical dialysis patients with arteriovenous fistulas and grafts and found that typical patients have correlated PAG spectra. PAGs can be analyzed using nonlinear, sub-band frequency-domain linear prediction to produce both bruit-enhanced recordings and a bruit-enhanced power envelope. This approach is novel over prior methods because it adaptively predicts signal envelopes based on physiologic properties of blood flow determined from chronic dialysis recipients. Our results indicate that a generalized bruit-enhancing filter can be developed for dialysis vascular access. Outputs from this filter may be analyzed to determine vascular physiology, including re-stenosis risk.
对血管杂音的主观分析长期以来一直是血管通路体格检查的一个组成部分。血流杂音的数字记录——血管音图(PAGs)——可能提供一种客观的、非成像的血管通路狭窄测量方法。我们分析了患有动静脉内瘘和移植物的典型透析患者的PAGs的长期稳定性,发现典型患者的PAG频谱具有相关性。可以使用非线性、子带频域线性预测来分析PAGs,以产生杂音增强记录和杂音增强功率包络。这种方法相对于先前的方法是新颖的,因为它基于从慢性透析患者确定的血流生理特性自适应地预测信号包络。我们的结果表明,可以为透析血管通路开发一种通用的杂音增强滤波器。可以分析该滤波器的输出以确定血管生理状况,包括再狭窄风险。