Sharma Manuja, Carson Matthew D, Graham Jasmine Y, Nelson Leonard Y, Patel Shwetak, Eric Seibel J
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:3738-3741. doi: 10.1109/EMBC.2018.8513280.
Undetected caries can lead to painful cavities and surgical restorations. Lack of proper detection tools makes caries prevention dependent on dentist's expertise and presents obstacles in oral health monitoring. To overcome this problem, we have developed a new approach to predict early stages of enamel demineralization caused by oral bacteria. These bacteria metabolize sugars in our food and produce organic acids that lead to cavities. Measuring the acidity level can help predict early stages of tooth decay. pH paper or pH electrodes can be used to monitor acidity, but neither are able to track pH levels in all dental locations. Our device, DpOW, is a noncontact optics-based pH device that uses changes in the spectral fluorescence of FDA allowed fluorescein dye to measure acidity levels in difficult to access dental locations such as occlusal fissures. A prototype has been tested over a wide pH range (7.12 to 3.89) and shown to track the change in pH with 0.94 correlation coefficient.
未被检测出的龋齿会导致疼痛的龋洞和手术修复。缺乏合适的检测工具使得龋齿预防依赖于牙医的专业知识,并且在口腔健康监测中存在障碍。为了克服这个问题,我们开发了一种新方法来预测由口腔细菌引起的牙釉质脱矿的早期阶段。这些细菌代谢我们食物中的糖分并产生导致龋洞的有机酸。测量酸度水平有助于预测龋齿的早期阶段。pH试纸或pH电极可用于监测酸度,但两者都无法跟踪所有牙齿部位的pH值。我们的设备DpOW是一种基于非接触光学的pH设备,它利用FDA批准的荧光素染料的光谱荧光变化来测量难以到达的牙齿部位(如咬合裂隙)的酸度水平。一个原型已经在很宽的pH范围内(7.12至3.89)进行了测试,并显示出以0.94的相关系数跟踪pH值的变化。