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erabutoxin B对青蛙脊髓乙酰胆碱释放及根电位的影响。

Effect of erabutoxin B on acetylcholine release and root potentials of the frog spinal cord.

作者信息

Nistri A, Arenson M S

出版信息

Eur J Pharmacol. 1978 Jan 15;47(2):245-8. doi: 10.1016/0014-2999(78)90398-9.

DOI:10.1016/0014-2999(78)90398-9
PMID:304413
Abstract

Erabutoxin b (ETX), a sea snake neurotoxin with neuromuscular blocking properties, slightly reduced resting ACh release from the isolated fron spinal cord. ETX did not affect ACh release evoked by antidromic stimulation of ventral roots but reduced the ventral-dorsal root potential and prolonged the dorsal-ventral root potential. The latter effect was associated with a reduction in the orthodromically evoked ACh release. It is suggested that ETX did not affect the presynaptic terminals of the motor axon collaterals and that its effects occurred at postsynaptic sites.

摘要

erabutoxin b(ETX)是一种具有神经肌肉阻断特性的海蛇神经毒素,它能使离体脊髓的静息乙酰胆碱释放量略有减少。ETX 不影响由腹根逆向刺激诱发的乙酰胆碱释放,但会降低腹 - 背根电位并延长背 - 腹根电位。后一种效应与顺向诱发的乙酰胆碱释放减少有关。研究表明,ETX 不影响运动轴突侧支的突触前终末,其作用发生在突触后部位。

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