Bent Brinnae, Williams Ashley J, Bolick Ryan, Chiang Chia-Han, Trumpis Michael, Viventi Jonathan
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:4591-4594. doi: 10.1109/EMBC.2018.8513117.
Chronic studies of flexible μECoG electrodes and the electrode-brain interface have been limited by the inability to assess tissue response over time. The electrophysiological system presented here combines epidural microelectrocorticographic (μECoG) recording capabilities with the ability to visualize tissue response over time through light microscopy and optical coherence tomography (OCT). With the ability to interchange both the electrode and the electronics, and a flushing port for injection of flushing saline and/or drugs, this 3D printed system has future applications in chronic electrophysiology, optogenetics, and advanced imaging methods.
对柔性微脑电图（μECoG）电极及电极-脑界面的长期研究一直受到无法长期评估组织反应的限制。本文介绍的电生理系统将硬膜外微脑电图（μECoG）记录功能与通过光学显微镜和光学相干断层扫描（OCT）随时间可视化组织反应的能力相结合。该3D打印系统能够互换电极和电子设备，并设有用于注入冲洗盐水和/或药物的冲洗端口，在慢性电生理学、光遗传学和先进成像方法方面具有未来应用前景。
