Duke University, Durham, NC, USA.
Clinics (Sao Paulo). 2011;66 Suppl 1(Suppl 1):25-32. doi: 10.1590/s1807-59322011001300004.
Neuroprosthetic devices based on brain-machine interface technology hold promise for the restoration of body mobility in patients suffering from devastating motor deficits caused by brain injury, neurologic diseases and limb loss. During the last decade, considerable progress has been achieved in this multidisciplinary research, mainly in the brain-machine interface that enacts upper-limb functionality. However, a considerable number of problems need to be resolved before fully functional limb neuroprostheses can be built. To move towards developing neuroprosthetic devices for humans, brain-machine interface research has to address a number of issues related to improving the quality of neuronal recordings, achieving stable, long-term performance, and extending the brain-machine interface approach to a broad range of motor and sensory functions. Here, we review the future steps that are part of the strategic plan of the Duke University Center for Neuroengineering, and its partners, the Brazilian National Institute of Brain-Machine Interfaces and the École Polytechnique Fédérale de Lausanne (EPFL) Center for Neuroprosthetics, to bring this new technology to clinical fruition.
基于脑机接口技术的神经假体有望恢复因脑损伤、神经疾病和肢体丧失而导致严重运动障碍的患者的身体活动能力。在过去的十年中，这项多学科研究取得了相当大的进展，主要是在执行上肢功能的脑机接口方面。然而，在构建完全功能性肢体神经假体之前，还需要解决许多问题。为了将脑机接口研究推向用于人类的神经假体开发，必须解决与提高神经元记录质量、实现稳定、长期性能以及将脑机接口方法扩展到广泛的运动和感觉功能相关的一系列问题。在这里，我们回顾了杜克大学神经工程中心及其合作伙伴巴西国家脑机接口研究所和洛桑联邦理工学院（EPFL）神经康复中心的战略计划中的未来步骤，以将这项新技术推向临床应用。
