Department of Radiological Science, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Clin Mol Hepatol. 2019 Mar;25(1):21-29. doi: 10.3350/cmh.2018.1007. Epub 2018 Nov 16.
Concurrent advancements in imaging and genomic biomarkers have created opportunities to identify non-invasive imaging surrogates of molecular phenotypes. In order to develop such imaging surrogates radiomics and radiogenomics/imaging genomics will be necessary; there has been consistent progress in these fields for primary liver cancers. In this article we evaluate the current status of the field specifically with regards to hepatocellular carcinoma and intrahepatic cholangiocarcinoma, highlighting some of the up and coming results that were presented at the annual Radiological Society of North America Conference in 2017. There are an increasing number of studies in this area with a bias towards quantitative feature measurement, which is expected to benefit reproducibility of the findings and portends well for the future development of biomarkers for diagnosis, prognosis, and treatment response assessment. We review some of the advancements and look forward to some of the exciting future applications that are anticipated as the field develops.
影像组学和放射组学/影像基因组学的发展是建立非侵入性分子影像学替代物的必要条件，这些领域在原发性肝癌的研究中取得了持续的进展。本文评估了该领域在肝细胞癌和肝内胆管细胞癌方面的现状，重点介绍了 2017 年北美放射学会年会上展示的一些新出现的结果。该领域的研究数量不断增加，偏向于定量特征测量，这有望提高研究结果的可重复性，并为未来开发用于诊断、预后和治疗反应评估的生物标志物提供良好的前景。我们回顾了一些进展，并期待随着该领域的发展，能够出现一些令人兴奋的未来应用。
