主动脉交叉钳夹期间多巴胺对肾功能的影响。
The effect of dopamine on renal function during aortic cross clamping.
作者信息
Salem M G, Crooke J W, McLoughlin G A, Middle J G, Taylor W H
机构信息
Halton General Hospital, Runcorn, Cheshire.
出版信息
Ann R Coll Surg Engl. 1988 Jan;70(1):9-12.
Eighteen male patients undergoing elective surgical reconstruction of the abdominal aorta were divided into two groups. Patients in Group I (nine) were given dopamine intravenously, in a dose of 2 micrograms/kg/min, during the first half of the period of cross-clamping, whilst those in Group II received dopamine during the second half. Each patient acted as his own control and for each, three periods were examined, namely: pre-clamp, clamping with dopamine and clamping without dopamine. Dopamine infusion during aortic clamping caused a significant rise in sodium output (P less than 0.01), potassium output (P less than 0.05), creatinine clearance (P less than 0.05) and urine output (P less than 0.05). We conclude that dopamine infusion during aortic clamping helps to protect the kidney from any deleterious effect of clamping.
18名接受腹主动脉择期手术重建的男性患者被分为两组。第一组（9名）患者在交叉阻断期的前半段静脉注射多巴胺，剂量为2微克/千克/分钟，而第二组患者在交叉阻断期的后半段接受多巴胺注射。每名患者均作为自身对照，对每名患者的三个时期进行了检查，即：阻断前、多巴胺阻断时和无多巴胺阻断时。主动脉阻断期间输注多巴胺导致钠排出量显著增加（P<0.01）、钾排出量增加（P<0.05）、肌酐清除率增加（P<0.05）和尿量增加（P<0.05）。我们得出结论，主动脉阻断期间输注多巴胺有助于保护肾脏免受阻断的任何有害影响。
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