Aucouturier P, Berthier M, Bonneau D, Preud'homme J L
Laboratoire d'Immunologie et Immunopathologie, CNRS UA 1172, Poitiers.
Arch Fr Pediatr. 1988 Apr;45(4):255-8.
Serum IgG subclass levels were measured by an immunoenzymatic assay with monoclonal antibodies in 225 normal children aged 1 to 17 years. Adult concentrations of IgG1 and IgG3 were reached early (2 to 3 years of age), with mean IgG1 level slightly higher in children than in adults, whereas IgG2 and IgG4 showed a slow increase. Mean IgG2 levels in children aged 13 to 17 were still significantly lower than in adults. The distribution of IgG4 levels in every age group was very heterogeneous, with a fair incidence of subthreshold concentrations especially before 5 years of age. These data must be taken into account when defining IgG subclass deficiencies in children.
采用免疫酶法和单克隆抗体检测了225名1至17岁正常儿童的血清IgG亚类水平。IgG1和IgG3在儿童早期（2至3岁）即达到成人浓度，儿童的平均IgG1水平略高于成人，而IgG2和IgG4则呈缓慢上升趋势。13至17岁儿童的平均IgG2水平仍显著低于成人。各年龄组IgG4水平分布差异很大，尤其是在5岁之前，亚阈值浓度的发生率较高。在定义儿童IgG亚类缺陷时必须考虑这些数据。
